_____________________________________________________________________________________________________ *Corresponding author: E-mail: cathdunrin08@gmail.com; J. Adv. Med. Pharm. Sci., vol. 25, no. 4, pp. 11-23, 2023 Journal of Advances in Medical and Pharmaceutical Sciences Volume 25, Issue 4, Page 11-23, 2023; Article no.JAMPS.100386 ISSN: 2394-1111 In silico Study of Ornithine Decarboxylase and HSP-90 Gene in the Anti-trypanosomal Activities of Annona muricata Annonaceae Innocent Bamidele Osho a , Isaac Abayomi Adebayo a , Olusola Olalekan Elekofehinti b and Catherine Olusunmibola Durojaye a* a Department of Animal Production and Health, Animal Parasitology and Microbiology Research Unit, Federal University of Technology, Akure, Nigeria. b Department of Biochemistry, Bioinformatics and Molecular Biology Unit, Federal University of Technology, Akure, Ondo State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors IBO and IAA did the conceptualization, supervision and editing. Author OOE and COD did the methodology, reviewing, formal analysis, writing and editing. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMPS/2023/v25i4611 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/100386 Received: 17/03/2023 Accepted: 22/05/2023 Published: 01/06/2023 ABSTRACT Aims: Trypanosomiasis is one of the neglected tropical diseases of Sub-Saharan Africa caused by the numerous species and sub-species of the protozoan genus Trypanosoma. Soursop, also known as Annona muricata (Annonaceae), is a prevalent tropical plant species renowned for its numerous medicinal properties, including the treatment of protozoan infections. The fundamental mechanism Original Research Article