ﻣﺠﻠﻪ ﭼﺸﻢ ﭘﺰﺷﻜﻲ ﺑﻴﻨﺎ- ﺩﻭﺭﻩ۱۴ - ﺷﻤﺎﺭﻩ۳ ) ﺑﻬﺎﺭ۱۳۸۸ ( ۲۶۲ Keratocyte Density in Normal and Keratoconic Corneas Using Confoscan Mohammad-Rabei H, MD; Rezaei-Kanavi M, MD; Javadi MA, MD; Rahimian S, MD Purpose: To compare keratocyte density between normal and keratoconic corneas in non-contact lens wearers. Methods: Confocal scanning was performed on 39 corneas of 26 patients with keratoconus and 28 corneas of 14 normal control subjects. None of the cases were contact lens wearer. All individuals underwent ophthalmic examination and computed topography in addition to confocal microscopy. Main outcome measures were anterior (10%), middle (33-67%) and posterior (10%) stromal keratocyte densities. Results: Mean age of the subjects was 27.7±6.6 (range 18-45) years. Mean keratocyte density in the control group was 736.7±65.6 cell/mm 2 in the anterior stroma, 623.4±72.6 cell/mm 2 in the middle stroma and 608.6±45.8 cell/mm 2 in the posterior stroma. Corresponding values in the keratoconus group were 787.9±103.5, 665.2±58.1 and 604.2±69.0 respectively. No significant difference was noted between the two groups regarding stromal keratocyte density; however stromal keratocyte density significantly decreased from anterior toward posterior stromal layers within both groups. Keratocyte density showed statistically insignificant decrease with aging. Keratocyte density was significantly higher in female subjects (P= 0.019). Conclusion: No significant difference was seen between normal and keratoconic corneas in terms of stromal keratocyte density. • Bina J Ophthalmol 2009; 14 (3): 262-267.                    ! "#  $!   د  ر    ١ ، ن ر  د  ي ٢ ،   د اد! ي ٣ ورا ر$  د   ن % ﻫﺪﻑ: ﻣﻘﺎ ﻳ ﺴﻪ ﺗﺮﺍﮐﻢ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﺩﺭ ﻻﻳﻪ ﻫﺎﻱ ﻣﺨﺘﻠﻒ ﺍﺳﺘﺮﻭﻣﺎﻱ ﻗ ﺮﻧ ﻴ ﻪ ﺩﺭ ﻣﺒﺘﻼﻳﺎﻥ ﺑﻪ ﻗﻮﺯ ﻗﺮﻧﻴﻪ ﻭ ﺍﻓﺮﺍﺩ ﻃﺒﻴﻌـﻲ ﺑـﺎ ﺍﺳـﺘﻔﺎﺩﻩ ﺍﺯ ﺍﺳﮑﻦ ﮐﺎﻧﻔﻮﮐﺎﻝ. ﺭﻭﺵ ﭘﮋﻭﻫﺶ: ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺮ ﺭﻭﻱ۳۹ ﭼﺸﻢ ﺍﺯ۲۶ ﺑ ﻴ ﻤﺎﺭ ﻣﺒﺘﻼ ﺑﻪ ﻗﻮﺯ ﻗﺮﻧﻴﻪ ﺑﺪﻭﻥ ﺳﺎﺑﻘﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﻟﻨﺰ ﺗﻤﺎﺳ ﻲ ﻭ۲۸ ﭼـﺸﻢ ﺍﺯ ۱۴ ﻓﺮﺩ ﻃﺒﻴﻌﻲ ﺑﺪﻭﻥ ﺳﺎﺑﻘﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﻟﻨﺰ ﺗﻤﺎﺳﻲ) ﮔﺮﻭﻩ ﺷﺎﻫﺪ( ﺍﻧﺠﺎﻡ ﺷﺪ. ﻫﻤﻪ ﺍ ﻓﺮﺍﺩ ﺗﺤﺖ ﺍﺭﺯ ﻳ ﺎﺑ ﻲ ﭼـﺸﻢ ﭘﺰﺷـﮑ ﻲ ﻭ ﺗﻮﭘـﻮﮔﺮﺍﻓ ﻲ ﺭﺍﻳﺎﻧﻪ ﺍﻱ ﻭ ﺍﺳﮑﻦ ﮐﺎﻧﻔﻮﮐﺎﻝ ﻗﺮﺍﺭ ﮔﺮﻓﺘﻨﺪ. ﺗﺮﺍﮐﻢ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﺩﺭ ﻧﻮﺍﺣ ﻲ ﻗ ﺪﺍﻣ ﻲ) ۱۰ ﺩﺭﺻﺪ ﻗﺪﺍﻣﻲ( ، ﻣ ﻴ ﺎﻧ ﻲ) ۶۷ - ۳۳ ﺩﺭﺻﺪ ﻣﻴﺎﻧﻲ( ﻭ ﺧﻠﻔ ﻲ) ۱۰ ﺩﺭﺻﺪ ﺧﻠﻔﻲ( ﺍﺳﺘﺮﻭﻣﺎ ﻱ ﻗﺮﻧ ﻴ ﻪ ﺍﻧﺪﺍﺯﻩ ﮔ ﻴ ﺮ ﻱ ﺷﺪ. ﻳﺎﻓﺘﻪ ﻫﺎ: ﺩﺭ ﻣﺠﻤـﻮﻉ۶۷ ﭼـﺸﻢ ﺍﺯ۴۰ ﺑ ﻴ ﻤـﺎﺭ ﺑـﺎ ﻣ ﻴـ ﺎﻧﮕ ﻴ ﻦ ﺳـﻨ ﻲ۶ / ۶ ± ۷ / ۲۷ ) ۴۵ - ۱۸ ﺳـﺎﻝ( ﺑﺮﺭﺳـﻲ ﺷـﺪﻧﺪ ﻣﻴـﺎﻧﮕﻴﻦ ﺗﻌـﺪﺍﺩ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﺩﺭ ﻣﻴﻠﻲ ﻣﺘﺮ ﻣﺮﺑﻊ، ﺩﺭ ﮔﺮﻭﻩ ﺷﺎﻫﺪ۶ / ۶۵ ± ۷ / ۷۳۶ ﺩﺭ ﻻ ﻳ ﻪ ﻗﺪﺍﻣ ﻲ، ۶ / ۷۲ ± ۴ / ۶۲۳ ﺩﺭ ﻻ ﻳـ ﻪ ﻣ ﻴـ ﺎﻧ ﻲ ﻭ۸ / ۴۵ ± ۶ / ۶۰۸ ﺩﺭ ﻻﻳﻪ ﺧﻠﻔﻲ ﺍﺳﺘﺮﻭﻣﺎ ﻭ ﺩﺭ ﮔﺮﻭﻩ ﻗﻮﺯ ﻗﺮﻧﻴﻪ۵ / ۱۰۳ ± ۹ / ۷۸۷ ﺩﺭ ﻻﻳﻪ ﻗـﺪﺍﻣ ﻲ، ۱ / ۵۸ ± ۲ / ۶۶۵ ﺩﺭ ﻻﻳـﻪ ﻣ ﻴـ ﺎﻧ ﻲ ﻭ۶۹ ± ۲ / ۶۰۴ ﺩﺭ ﻻ ﻳـ ﻪ ﺧﻠﻔ ﻲ ﺍﺳﺘﺮﻭﻣﺎ ﺑﻮﺩ. ﺗﻔﺎﻭﺕ ﺑ ﻴ ﻦ ﺗﻌﺪﺍﺩ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﻱ ﺍﺳﺘﺮﻭﻣﺎ ﻱ ﻗﺮﻧ ﻴ ﻪ ﺩﺭ ﻻﻳﻪ ﻫﺎﻱ ﻣﺘﻨﺎﻇﺮ ﺩﺭ ﺩﻭ ﮔﺮﻭﻩ ﻣﻌﻨﻲ ﺩﺍﺭ ﻧﺒـﻮﺩ ﻭﻟـﻲ ﺗﻌـﺪﺍﺩ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﺩﺭ ﻫﺮ ﮔﺮﻭﻩ، ﺍﺯ ﻻ ﻳ ﻪ ﻫﺎ ﻱ ﻗﺪﺍﻣ ﻲ ﺑﻪ ﺳﻤﺖ ﻻ ﻳ ﻪ ﻫﺎ ﻱ ﺧﻠﻔ ﻲ ﺑﻪ ﻃﻮﺭ ﻣﻌﻨﻲ ﺩﺍﺭﻱ ﮐﺎﻫﺶ ﻣﻲ ﻳ ﺎﻓﺖ. ﺑﺎ ﺍﻓﺰﺍﻳﺶ ﺳﻦ، ﺗﻌـﺪﺍﺩ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﮐ ﺎﻫﺶ ﻣﻲ ﻳﺎﻓﺖ ﺍﻣﺎ ﺍ ﻳ ﻦ ﮐﺎﻫﺶ ﺍﺯ ﻧﻈﺮ ﺁﻣﺎﺭ ﻱ ﻣ ﻌ ﻨ ﻲ ﺩﺍﺭ ﻧﺒﻮﺩ. ﺗﺮﺍﮐﻢ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﺩﺭ ﻗﺮﻧ ﻴ ﻪ ﺍﻓﺮﺍﺩ ﻣﺬﮐﺮ ﻧﺴﺒﺖ ﺑﻪ ﺍﻓﺮﺍﺩ ﻣﻮﻧﺚ ﮐﻢ ﺗﺮ ﺑﻮﺩ) ۰۱۹ / ۰  ( . ﻧﺘ ﻴ ﺠﻪ ﮔ ﻴ ﺮ ﻱ: ﺗﻔﺎﻭﺕ ﻣﺸﺨﺼ ﻲ ﺑ ﻴ ﻦ ﺗﻌﺪﺍﺩ ﮐﺮﺍﺗﻮﺳ ﻴ ﺖ ﻫﺎ ﻱ ﺍﻓﺮﺍﺩ ﻃﺒﻴﻌﻲ ﻭ ﺍﻓﺮﺍﺩ ﻣﺒﺘﻼ ﺑﻪ ﻗـﻮﺯ ﻗﺮﻧﻴـﻪ ﮐـﻪ ﺍﺯ ﻟﻨـﺰ ﺗﻤﺎﺳـ ﻲ ﺍﺳـﺘﻔﺎﺩﻩ ﻧﻤ ﻲ ﮐ ﺮﺩﻧﺪ ؛ ﻭﺟﻮﺩ ﻧﺪﺍﺭﺩ. Downloaded from binajournal.org at 4:43 +0330 on Monday November 29th 2021