Brief Report Rapid Assessment at Hospital Admission of Mortality Risk From COVID-19: The Role of Functional Status Olga Laosa PhD a, b , Laura Pedraza MD b , Alejandro Álvarez-Bustos MSc b , Jose A. Carnicero PhD a, b , Fernando Rodriguez-Artalejo PhD c, d, e , Leocadio Rodriguez-Mañas PhD a, f, * a Centre of Network Biomedical Research on Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain b Institute of Biomedical Research, University Hospital of Getafe, Getafe, Madrid, Spain c Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain d IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz), Madrid, Spain e CIBERESP (CIBER of Epidemiology and Public Health), IMDEA-Food Institute, CEI UAMþCSIC, Madrid, Spain f Geriatrics Department, University Hospital of Getafe, Getafe, Madrid, Spain Keywords: COVID-19 function disability mortality intensive care Barthel Index abstract Objective: To evaluate the role of functional status along with other used clinical factors on the occur- rence of death in patients hospitalized with COVID-19. Design: Prospective cohort study. Setting: Public university hospital (Madrid). Participants and Methods: A total of 375 consecutive patients with COVID-19 infection, admitted to a Public University Hospital (Madrid) between March 1 and March 31, 2020, were included in the Pro- spective Cohort study. Death was the main outcome. The main variable was disability in activities of daily living (ADL) assessed with the Barthel Index. Covariates included sex, age, severity index (Quick Sequential Organ Failure Assessment, qSOFA), polypharmacy (5 drugs in the month before admission), and comorbidity (3 diseases). Multivariable logistic regression was used to identify risk factors for adverse outcomes. Estimated model coefficients served to calculate the expected probability of death for a selected combination of 5 variables: Barthel Index, sex, age, comorbidities, and severity index (qSOFA). Results: Mean age was 66 years (standard deviation 15.33), and there were 207 (55%) men. Seventy-four patients died (19.8%). Mortality was associated with low Barthel Index (odds ratio per 5-point decrease 1.11, 95% confidence interval 1.03-1.20), male sex (0.23, 0.11-0.47), age (1.07, 1.03-1.10), and comorbidity (2.15, 1.08-4.30) but not with qSOFA (1.29, 0.87-1.93) or polypharmacy (1.54, 0.77-3.08). Calculated mortality risk ranged from 0 to 0.78. Conclusions and Implications: Functional status predicts death in hospitalized patients with COVID-19. Combination of 5 variables allows to predict individual probability of death. These findings provide useful information for the decision-making process and management of patients. Ó 2020 AMDA e The Society for Post-Acute and Long-Term Care Medicine. In December 2019, the first case of SARS-CoV-2 infection was re- ported in Wuhan, China, 1 resulting in an outbreak that was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). 2 COVID-19 pandemic has had a major impact in the Madrid region, where 27,509 cases and 3603 deaths were registered on the same date (March 31, 2020, the last date of inclusion in our study). 3 Regarding age distribution, 86% of deaths have occurred in patients older than 70 years and 95% if we extend to those older than 60 years. Mortality reaches greater than 60% for patients aged 80 years. 4 Taking this fact into account, it should be expected that relevant Competing interests: Authors state that there are not conflicts of interest This work is supported by grants from Cofinanced by the European Regional Development Fund (RD) 120001/0043 and Centro de Investigacion Biomédica en Red en Fragilidad y envejecimiento saludable-CIBERFES (CB 16/10/00464), Institute of Health Carlos III, Madrid, Spain. The authors declare no conflicts of interest. * Address correspondence to Leocadio Rodriguez-Mañas, PhD, Hospital Uni- versitario de Getafe (Geriatrics Department), Carretera de Toledo Km 12,500, 28905 Getafe (Madrid), Spain. E-mail address: leocadio.rodriguez@salud.madrid.org (L. Rodriguez-Mañas). https://doi.org/10.1016/j.jamda.2020.10.002 1525-8610/Ó 2020 AMDA e The Society for Post-Acute and Long-Term Care Medicine. JAMDA journal homepage: www.jamda.com JAMDA 21 (2020) 1798e1802