© 2020. M. C. O. Ezeibe, M. I. Ezeja, C. A, Akpan, F. I.O. Onyeachonam, M. E. Sanda, I. J. Ogbonna, E. Kalu, N.U. Njoku & M.I. Udobi. This is a research/review paper, distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Antivirt ® {Al 4 (Sio 4 ) 3 + 3Mg 2 SiO 4 → 2Al 2 Mg 3 (Sio 4 ) 3 } Enhances Efficacy of Co-trimoxazole to Terminate Experimental Trypanosome-Infections in Mice By M. C. O. Ezeibe, M. I. Ezeja, C. A, Akpan, F. I.O. Onyeachonam, M. E. Sanda, I. J. Ogbonna, E. Kalu, N.U. Njoku & M.I. Udobi Michael Okpara University of Agriculture Abstract- Both bacteria and protozoa require Folic acid for replication and Cotrimoxazole inhibits synthesis of the vitamin. For its mechanism of inhibiting Folic acid, the medicine has been in use as antibacterial drug for many decades but it is not being used to treat trypanosomosis (protozoan disease). To enhance anti-Folic acid activity of the medicine in order to improve its anti-trypanosome efficacy and make it function as new medicine for sleeping sickness (tropical disease of man and animals) it was stabilized with Antivirt® (Medicinal synthetic Aluminum-magnesium silicate). At 100 % of its antibacterial dose, Cotrimoxazole significantly reduced (P ≤ 0.05) trypanosome parasitemia in mice, from 12.76±1.20 to 5. 87± 0.43. When it was stabilized with the Antivirt®, 75 % of the antibacterial dose had slight reduction (P ≥ 0.05) in the trypanosome parasitemia (11.30±1.01) while the 100 % -dose achieved zero (0.00±00) trypanosome parasitemia and improved total WBC counts (immunity) from 1.50±0.16 to 2.86±0.38. Keywords: cotrimoxazole; folic acid-inhibition; anti-trypanosomes efficacy; antivirt®; sleeping sickness, new medicine. GJMR-G Classification: NLMC Code: QW 70 Strictly as per the compliance and regulations of: Global Journal of Medical Research: G Veterinary Science and Veterinary Medicine Volume 20 Issue 3 Version 1.0 Year 2020 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Online ISSN: 2249-4618 & Print ISSN: 0975-5888 AntivirtAl4Sio433Mg2SiO42Al2Mg3Sio43EnhancesEfficacyofCotrimoxazoletoTerminateExperimentalTrypanosomeInfectionsinMice