Combination of Radiofrequency and Intralesional Steroids in the Treatment of Keloids: A Pilot Study Ahmed Hany Weshay, MD,* Rania Mounir Abdel Hay, MD,* Khadiga Sayed, MD,* Marwa Safwat El Hawary, MD,* and Faisal Nour-Edin, MD † BACKGROUND None of therapeutic options for the treatment of keloids has been found completely effective and satisfactory. A combination approach is the best modality. OBJECTIVE To assess the clinical safety and efficacy of radiofrequency (RF) followed by intralesional (IL) steroid injection in keloids. MATERIALS AND METHODS This pilot study included 18 patients who were suffering from keloids. All patients were subjected to 3 to 4 sessions of RF followed by IL steroid injection. Assessment of the scar volume and both objective and subjective parameters has been performed before and after completion of the sessions. RESULTS There was a significant reduction of volume of all lesions in all patients after a total of 3 to 4 sessions (p = .001), with a mean volume reduction of 95.4%. There was a significant reduction of keloid pli- ability, height, and erythema compared with baseline (p < .001). Patients reported a significant reduction of their subjective symptoms compared with baseline (p < .001). No pain, infection, nor bleeding were reported after the RF procedure. CONCLUSION Radiofrequency tissue volume reduction combined with IL steroid is an effective treatment modality for keloids. It is an easy procedure with acceptable cosmetic outcome and less rate of recurrence. The authors have indicated no significant interest with commercial supporters. K eloids are cosmetically disfiguring disorder characterized by benign fibrous outgrowths. They represent a major therapeutic dilemma because of their frequent recurrence. 1 Despite wide therapeutic options available for these scars, none has been found to be completely effective and satisfactory. 2,3 A combination approach to therapy seems to be the best modality. 4 Intralesional (IL) steroid injections induce only soft- ening and flattening of the keloids but cannot make them disappear when used alone. 5 The radiofrequency (RF) therapy has been used in cosmetic medicine. 6 Radiofrequency tissue volume reduction (RFTVR) is a surgical technique that induces extensive fibrosis at the treated tissues. 7 Because of its mechanism of action, it was considered as a suitable modality for the treatment of keloids. 7 The aim of this study was to assess the clinical safety and efficacy of RF followed by IL injection of steroids in the treatment of keloids. Using RF can help us to get rid of the fibrous mass by destruction, not by surgery to avoid being under tension of the new scar. Materials and Methods This pilot study included 21 patients with skin pho- totype II to IV and suffering from keloidal lesions. All patients were collected from Dermatology Outpatient Clinic, Faculty of Medicine, Cairo University, Egypt. Of the 21 patients who were enrolled in the study, 18 completed the study. The study protocol conformed to the Ethical Guidelines of the 1975 Declaration of Helsinki. Each patient signed a written informed consent, and alternative treatments were explained *Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt; † Department of Dermatology, National Research Centre, Cairo, Egypt © 2015 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved. ISSN: 1076-0512 · Dermatol Surg 2015;41:731–735 · DOI: 10.1097/DSS.0000000000000360 731 © 2015 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.