J Cardiovasc Disease Res., 2017; 8(2):38-41 A Multifaceted Peer Reviewed Journal in the feld of Cardiology www.jcdronline.org | www.journalonweb.com/jcdr 38 Journal of Cardiovascular Disease Research, Vol 8, Issue 2, Apr-Jun, 2017 Original Article Correspondence Dr Mukul Kumar, Assistant Professor, Depart- ment of Cardiology, Dr Rajendra Prasad Govt. Medical College, Kangra at Tanda, Himachal Pradesh, India. Mobile No: +91-9418703760 E-mail address: drmukulpgi@ gmail.com Submission Date: 16-01-2017; Revision Date: 16-02-2017; Accepted Date: 27-02-2017. DOI : 10.5530/jcdr.2017.2.9 ABSTRACT Background: The etiology of the ventricular dilation and dysfunction that occurs in idiopathic dilated cardiomyopathy (DCM) is unknown. Aim: The present study was aimed to study clinical characteristics of the patients admitted with idiopathic DCM and compare them with healthy controls. Methods: Thirty newly diagnosed patients with DCM and 30 healthy control were enrolled from Cardiology OPD, PGIMER, Chandigarh from Jan 2011 to Jun 2012. Patients with heart failure secondary to idiopathic DCM of age >18 years were included if they were willing, provide written informed con- sent and does not meet any of the exclusion criteria. Idiopathic DCM was diagnosed by the presence of left ventricular dilatation and systolic dysfunction (LVEF<40%) on echocardiography in the absence of coronary artery disease, hyper- tension or valvular disease. Results: Mean age of idiopathic DCM patients and control was 48.37 ± 10.82 years and 49.2 ± 9.27 (P=0.75) respectively. There were more males (66.7%) than females (33.3%) in the patient group. It was observed that the treatment with beta blockers, furosemide, spironolactone, ACE inhibitors, and ARBs signifcantly im- proved ejection fraction (EF) (P=0.000), and LVES (P=0.000). Conclusion: In our study, treatment with the medications signifcantly improved EF and LVES. However, there was no treatment-based difference in the patients on ACE inhibitors or ARBs in the improvement in EF. Our study also observed signifcance difference in platelets count, SGOT, SGPT, and LDL levels in idiopathic DCM patients when compared with healthy controls. Key words: DCM, LVEF, LVES, NYHA Class, ACE Inhibitors, ARBs. Mukul Kumar 1 , Yashpaul Sharma 2 , Ajay Bahl 2 1 Assistant Professor, Department of Cardiology, Dr Rajendra Prasad Government Medical College, Kangra at Tanda, Himachal Pradesh, INDIA. 2 Department of Cardiology, Post Graduate Institute of Medical Education & Research PGIMER, Chandigarh, INDIA. Comparative Analysis of Clinical Profle of Patients Admitted with Idiopathic Dilated Cardiomyopathy in a Tertiary Care Hospital INTRODUCTION Background Dilated Cardiomyopathy (DCM) refers to a group of heterogenous myocardial disorders that are characterized by ventricle dilation and depressed myocardial contractility in the absence of abnormal loading conditions (such as hypertension or valvular disease) or ischemic heart disease sufcient to cause global systolic impairment. 1,2 Te term idio- pathic DCM refers when etiology is not known. It is much more com- mon than the other major forms of cardiomyopathy (hypertrophic, re- strictive and arrhythmogenic right ventricular cardiomyopathy). It is a heterogeneous disease characterized by ventricular and sometimes atrial dilatation, with normal or reduced wall thickness, eventually leading to varying degrees of impaired systolic function. Te clinical picture at the time of diagnosis can vary widely from patient to patient; some have no symptoms, whereas others have progressive refractory heart failure. De- pending on the diagnostic criteria used, the reported annual incidence varies between 5 and 8 cases per 100,000 population. 3 Males have a 2.5- fold increase in risk, as compared with females, that is unexplained by socioeconomic factors, alcohol intake, or other variables. 4 Patients with idiopathic DCM can present a highly variable clinical course. Te chal- lenge is to identify and treat the known and treatable causes of idiopathic DCM early enough to improve symptoms and survival. Te present study was aimed to study clinical characteristics of the patients admitted with idiopathic DCM and compare them with healthy controls. Subjects and Methods Tis prospective study was conducted at Department of Cardiology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh from Jan 2011 to Jun 2012. Tirty newly diagnosed patients of DCM were enrolled in the study from cardiology OPD. Similar num- bers of healthy controls were also enrolled. Attendants of the patients were enrolled as healthy subjects. Patients with heart failure secondary to idiopathic cardiomyopathy of age >18 years were included if they were willing, provide written informed consent and does not meet any of the exclusion criteria. A similar number of age- and sex-matched controls were included in the study. Idiopathic dilated cardiomyopathy was di- agnosed by the presence of lef ventricular dilatation and systolic dys- function (LVEF<40%) on echocardiography in the absence of coronary artery disease, hypertension or valvular disease. Te patients who were unwilling to participate, smokers, with coronary artery disease, diabe- tes mellitus, cancer, hypercholesterolemia, with concomitant infection at time of study, on sildenafl tablet, pregnancy, with peripheral vascular disease, presence of other serious co-morbid medical or surgical illness, renal failure or autoimmune disease, rheumatic heart disease, hypertro- phic cardiomyopathy, hypertensive heart disease, congenital heart dis- ease, evidence of restrictive or constrictive physiology, or alcohol intake > 60g/day were excluded from study. Te study was conducted following approval from Institutional Ethics Committee. Afer written informed consent, a detailed history was taken and thor- ough physical examination was carried out especially with reference to the risk factors for coronary artery disease. Blood investigations in the form of hemogram, liver function tests, renal function tests and lipid profle were done.