correlation between both: well-being and the possibility of making physical effort, and nutritional status (BMI) of patients with CF: r = 0.421 p < 0.012 and r = 0.433, p < 0.009, respectively. Conclusions: In the analyzed group of patients with CF nutritional status is strongly related to respiratory efficiency, physical activity, carbohydrate metabolism and well-being. However, BMI above normal does not improve spirometry parameters. Disclosure of Interest: None declared. MON-PO444 EFFECTS OF DAILY CONSUMPTION OF YOGHURT ENRICHED WITH VITAMINS B IN COMPARISON TO PLAIN YOGHURT ON TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICALTRIAL P. Binou 1* , A. Yanni 1 , V. Karathanos 1 , K. Kartsioti 1 , A. Chatzigeorgiou 2 , D. Perrea 3 , P. Konstantopoulos 3 , N. Tentolouris 3 , A. Kokkinos 3 . 1 Nutrition and Dietetics, Harokopio University of Athens, 2 DELTA S.A, 3 Medical School, National and Kapodistrian University of Athens, Athens, Greece * Corresponding author. Rationale: Vitamins B exert multifunctional roles in energy metabol- ism while in the state of Type 2 Diabetes (T2D) the requirements may be higher. Yoghurt naturallycontains vitamins of the B-complex and enrichment with other members of this vitamin class could offer additional health benefits. The study investigates the effects of consumption of yoghurt enriched with vitamins B1, B5 and B6 compared to plain yoghurt, on T2D patients. Methods: Twenty-eight (N = 28, men 75%, age 45–75) overweight/ obese T2D patients (BMI 27–36 kg/m 2 ) were randomized to a 12 week dietary intervention characterized by the consumption of two servings per day (2 × 200 g) of non-fat yoghurt either strawberry flavored enriched with vitamins B1, B5 and B6 in a minimum of 15% of the recommended dietary intakes per 100 g (VY) or isocaloric plain yoghurt (PY). Anthropometric characteristics, fasting plasma glucose and insulin, glycosylated haemoglobin (HbA 1 C) and basal biochemical parameters were measured. Concentrations of vitamins B and homocysteine were also determined in VY group. Results: At the end of the dietary intervention body weight and BMI and were reduced in VY group (P = 0.04 and P = 0.04, respectively) and there was a trend for reduction in HbA 1 C(P = 0.08), while they remained unchanged in PY group compared to baseline values. In VY group, concentrations of B2 and B6 were increased (P = 0.04 and P =0.006, respectively) and there was a trend for increase in B1 levels (P =0.09). A trend towards reduction in homocysteine levels was also observed (P = 0.06). Conclusions: Inclusion of a non-fat yoghurt enriched with vitamins B in the daily dietary pattern facilitates body weight management, increases vitamins B concentration and ameliorates homocysteine levels of overweight/obese T2D patients. Disclosure of Interest: None declared. MON-PO445 IMPACT OF BODY MASS INDEX IN THE OCCURRENCE OF IDIOPATHIC DEEP VEIN THROMBOSIS AND IN THE QUALITY OF LIFE OF GREEK NURSES P. Koskinas 1 , G. Intas 2* , P. Stergiannis 3 , G. Panoutsopoulos 4 . 1 Outpatient Department, Panarcadiko Hospital, Tripoli, 2 Medical Department, General Hospital of Nikaia ‘Agios Panteleimon’, Nikaia, 3 Administration Office, Oncology Hospital of Agioi Anargyroi, Athens, 4 Nursing, University of Peloponese, Keratsini, Greece * Corresponding author. Rationale: Idiopathic deep vein thrombosis (DVT) is a common disease with high prevalence and various risk factors. The aim of the study was to investigate the role of body mass index (BMI) at the incidence of DVT in nursing staff of Greek hospitals and the effect of BMI at the quality of their life (QoL). Methods: This is a multi-center descriptive correlation study, including nurses of Greek hospitals. Estimation of deep vein thrombosis was done with the clinical criteria of Hicks or by diagnosis by clinician. QoL was assessed using the SF-36 questionnaire. One-way Anova analysis was used for the statistical analysis of the data. Results: The study sample consists of 3152 nurses. Totally, 896 (28.4%) subjects had normal weight, 2143 (68%) were overweight and 113 (3.6%) were obese. Obese patients rather than normal and overweight patients have lower level of exercise (4.5 ± 0.8 vs. 3.4 ± 1.1 vs. 3.8 ± 0.9, p < 0.001), increased rate of diagnosis of DVT by physician (45.1% vs. 2.7% vs. 9.2%, p < 0,001) and 3 or more criteria of DVT (60.2% vs. 14.1% vs. 25.3%, p < 0,001), and lower score of physical function (35.7 ± 38.8 vs. 85.1 ± 28.6 vs. 74.1 ± 35.3, p < 0,001), role limitations due to physical health (38.9 ± 42.4 vs. 84.9 ± 31.4 vs. 73.6 ± 36.9, p < 0,001), role limitations due to emotional problems (38.1 ±41.8 vs. 83.1 ±33.3 vs. 72.5 ± 38.5, p < 0,001), energy/fatigue (44.7 ± 22.1 vs. 57.9 ± 19.8 vs. 57.1 ± 20.2, p < 0,001), emotional well-being (53.6 ± 18.1 vs. 66.4 ± 18.9 vs. 66.1 ± 17.9, p < 0,001), social functioning (52.4 ± 37.2 vs. 87.7 ± 22.5 vs. 80.6 ± 31.1, p < 0,001), pain (39.8 ± 39.2 vs. 82.6 ± 29.1 vs. 74.7 ± 36.4, p < 0,001) and general health (42.9 ± 22.9 vs. 65.7 ± 16.8 vs. 60.4 ± 19.1, p < 0,001). The advanced BMI was found to be prognostic factor for DVT (β = -0.323, OR = 1.381, 95% CI: 1.302–1.464). Conclusions: Increased BMI is a risk factor for DVT in nurses and negatively affects their QoL. Disclosure of Interest: None declared. MON-PO446 A PRELIMINARY QUALITATIVE STUDY OF GENERAL PRACTITIONERS’ VIEWS ON MALNUTRITION MANAGEMENTAND ORAL NUTRITIONAL SUPPLEMENTATION PRESCRIPTION IN THE COMMUNITY P. Dominguez Castro 1,2 , S. Kennelly 3 , B. Clyne 4 , G. Bury 5 , C. Bradley 6 , K. Finnigan 7 , L. McCullagh 7 , M. Barry 7 , C. Murrin 1,2 , C. Perrotta 1,2 , K. Loayza Villaroel 1,2 , C. Reynolds 1,2 , E. Gibney 1,8 , C. Corish 1,2* . 1 Institute of Food and Health, University College Dublin, Dublin, Ireland, 2 School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, 3 National Primary Care Division, Community Funded Schemes Service Improvement, Health Service Executive, Co Laois, Ireland, 4 HRB Centre for Primary Care Research,Department of General Practice, Royal College of Surgeons in Ireland, Ireland, 5 School of Medicine, University College Dublin, Dublin, Ireland, 6 Royal College of Surgeons in Ireland, Dublin, Ireland, 7 Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, Trinity College Dublin, Ireland, 8 School of Agriculture and Food Science, University College Dublin, Dublin, Ireland * Corresponding author. Rationale: Oral nutritional supplements (ONS) are effective in managing malnutrition when prescribed for the right patients. Previous research indicates that inappropriate prescribing of ONS occurs frequently in the community. Previous Irish research has demonstrated low awareness of malnutrition and its management among non-dietetic health care professionals. In Ireland, general practitioners (GPs) are the main prescribers of ONS in primary care. On many occasions GPs are the first point of contact for individuals in the community at risk of malnutrition. GPs’ views can provide insight into the complexities of managing malnutrition and ONS prescribing in the community. Methods: Semi-structured interviews with nine GPs. Domains explored; Barriers and facilitators managing malnutrition and ONS prescribing. Data was transcribed and analysed using inductive thematic analysis. S223 Abstracts / Clinical Nutrition 38 (2019) S59–S296