_____________________________________________________________________________________________________ *Corresponding author: E-mail: ntiamoah13@gmail.com, david.ntiamoah@uenr.edu.gh; Asian Hematology Research Journal 1(4): 1-7, 2018; Article no.AHRJ.47124 Evaluation of the Diagnostic Value of Ret-He among Sickle Cell Disease Children with Iron Deficiency Anaemia on Haematinics David Ntiamoah Ofosu 1,2,3* , Clement Opoku-Okrah 2,3 , Victoria Bam 4 and Selorm Philip Segbefia 1 1 Department of Medical Laboratory, Garden City University College, Ghana. 2 Department of Medical Laboratory Technology, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Ghana. 3 Department of Haematology, Komfo Anokye Teaching Hospital, Ghana. 4 Department of Nursing, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Ghana. Authors’ contributions This work was carried out in collaboration among all authors. Authors DNO and COO designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors DNO, COO and VB managed the analyses of the study. Authors DNO, SPS and VB managed the literature searches. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Rohit Jain, Department of Pathology, Santokba Durlabhji Memorial Hospital, Jaipur, India. Reviewers: (1) Shigeki Matsubara, Jichi Medical University, Japan. (2) Karen Cordovil, FIOCRUZ, Brasil. (3) Noha Mohamed Kamel, Suez Canal University, Egypt. Complete Peer review History: http://www.sdiarticle3.com/review-history/47124 Received 07 December 2018 Accepted 26 February 2019 Published 12 March 2019 ABSTRACT Introduction: The determination of the amount of hemoglobin in reticulocytes provides a more real- time assessment of the iron status of the bone marrow. Ret-He, the iron molecule found in reticulocytes, unlike most biochemical markers is not affected by inflammation. Hence its determination provides a better way of detecting the presence or absence of iron for erythropoiesis. Objectives: The aim of the study was to evaluate the diagnostic value of Ret-He and to compare it with serum ferritin and Red Blood Cell (RBC) indices: haemoglobin (Hb), Mean Corpuscular Original Research Article