iMedPub Journals www.imedpub.com 2015 Vol. 1 No. 1: 1 1 Journal Of Medical Physics And Applied Sciences ISSN 2574-285X Short Communication © Under License of Creative Commons Attribution 3.0 License | Find this article in: www.medicalphysics.imedpub.com DOI: 10.21767/2574-285X.100001 Ranjit K. Sahu 1,2 and Shaul Mordechai 2 1 Department of Medicine, University of Virginia, Charlotesville, Virginia, 22908 USA 2 Department of Physics and the Cancer Research Center, Ben Gurion University, Beer-Sheva, 84105, Israel Corresponding author: Shaul Mordechai  shaulm@bgu.ac.il Department of Physics and the Cancer Research Center, Ben Gurion University, Beer-Sheva, 84105, Israel. Tel: +972 8-646-1600 Citation: Pagliaro G. Applying at a distance of meditaton Tong Len on a group of cancer patents to measure the psychological efects. Insights Med Phys. 2015, 1:2. Introducton Research into the utlizaton of FTIR based spectroscopic methods has been going on for close to about 25 years with the feld expanding from the inital days of cancer diagnosis to now where it includes various diseases occurring due to pathogens, genetc and environmental factors as well as lifestyle and age related factors. In parallel there have been developments in terms of both instrumentaton sophistcaton and computatonal methods, to make it more clinically appealing while increasing the sensitvity and specifcity of the technique. As the feld has diversifed over the years, a few reports are highlighted that establish the growing acceptance of FTIR spectroscopy as a reliable technique in both basic and applied research in the feld of biomedicine. The feld of IR based diagnosis emerged with the validatons that carcinogenic and normal tssues from various organs could be diferentated based on their absorbance in the IR region (mostly mid-IR) that was related to the alteraton in the chemical compositon [1-4]. The concept of unique fngerprintng was subsequently well established with studies from many diferent laboratories reportng that each cell or tssue type ranging from microbial cell [5] to complex human tssues have characteristc absorbance spectrum [6-8]. Making the system of diagnosis reagent free has been the ultmate challenge in using the technique in routne clinical set ups. While computatonal analysis for data processing were contnuously being developed to increase the sensitvity and specifcity of the technology, progress has also been made to provide a unique platorm for predictng diseases from examinaton of biopsies [9,10]. This in turn is expected to pave the way for real tme diagnosis at the site of surgery. Similarly, the ability to utlize both the transverse [11] as well as longitudinal sectons [10] of a biopsy for obtaining informaton on the status of complex tssues like colon provides a unique potental to FTIR based measurements compared to conventonal techniques like Immunofuorescence. Likewise the ability to predict the abnormality from both higher and lower wavenumbers of the spectra independently or in combinaton using biomarkers derived from spectral data and the possibility of using common biomarkers for several diseases have led to the possibility of deployment of this technique in clinical setng for a variety of disease diagnosis [12,13]. Though the feld began with studies on cancerous tssues which were used as samples in the inital period owing to their well defned architecture it has since expanded to other types of tssue abnormalites [14] and utlizaton of animal models [15]. Malignant tssues, melanoma and other types of abnormal tssues have been used for an altogether diferent purpose, namely as model systems for development of computatonal methods to analyze the data to increase the specifcity and sensitvity of the technology. This is one aspect of the technology that has been steadily progressing with the interdisciplinary research and sofware development. The earliest studies depended heavily on spectral diferences that were obvious either as wavenumber shifs or as changes in band intensites or efectve ratos derived from intensites at wavenumber corresponding to originate from biological components, for classifcaton of normal and abnormal tssues [1,2,7,11-13]. As the feld progressed, the advanced techniques like cluster analysis and linear discriminant analysis (LDA) were developed to make the data analysis more objectve. Further improvements and applicaton of mathematcal propositons has been leading to methods which enable categorizaton of spectral data which have very low variability by the earlier techniques, enabling The Increasing Relevance of FTIR Spectroscopy in Biomedicine Received: October 28, 2015; Accepted: November 18, 2015; Published: November 28, 2015