Clinical Therapeutics e64 Volume 37 Number 8S Conclusion: The knowledge of DRESS syndrome clinical symptoms in children is essential for clinicians. It is especially important that pediatricians should be able to take this life-threatening syndrome into consideration for differential diagnosis. Early diagnosis and immediate cessation of the suspected drug is primordial to prevent potentially fatal outcomes. ETHNIC NORWEGIAN DOCTORS AND DIABETIC PAKISTANI WOMEN IN OSLO - WHAT IS THE PATIENTS' NEED FOR INFORMATION? E.-L. Toverud; W. Abuelmagd; K. Mahmood; N. Taghizadeh; M. Jakovljevic; and H. Håkonsen School of Pharmacy, University Of Oslo, Oslo, Norway Background: The Pakistanis constitute a big immigrant population in Oslo with a high prevalence of diabetes. The aim of the project was to study challenges Norwegian GPs experience with non-western immigrants, and what knowledge diabetic Pakistani women have about their disease, and their need for information. Material and Methods: The material was 22 ethnic Norwegian GPs with many immigrant patients, and 125 diabetic Pakistani women (29–80 y old), recruited through mosques and female networks. All participants were interviewed personally with structured question- naires; the women in their homes. Approval was obtained from the Norwegian Social science data services. Results: The main obstacle for the GPs was language. Consequently it was difficult to diagnose and to explain drug treatment. The main chronic disease was diabetes. The doctors could see from blood levels how drug adherence decreased during Ramadan. The language was the main challenge also for the patients, even with an average stay of 30 years in Norway. Seventy percent had to be interviewed in Urdu; 27% were illiterates. Almost 40% reported poor/very poor health status. Above half did not know their type of diabetes. The treatment was tablets for 70%, insulin for 4% and both medication forms for 24%. Twenty-five percent altered their medication intake during Ramadan. Macrovascular diseases were widely spread among all ages. Number of meals per day was too low according to guide- lines. Two third admitted high calorie intakes between meals. Physical activity was reported by 46%. The majority could only benefit from oral information, and in Urdu. Most participants primarily missed information about the drugs they were using. Conclusion: The study shows how cultural and religious barriers prevent Norwegian doctors to have a good communication with non-Western patients and also how difficult it is for diabetic Pakistani women to get the right information about their disease. EFFECT OF MEDICATION REVIEW AND PHYSICIAN TRAINING PROGRAMME ON DRUG RELATED EVENTS IN HIGH RISK SURGICAL PATIENTS (P-REVIEW STUDY) J.M. Bos 1 ; P.M.L.A. van den Bemt 2 ; H. Pot 3 ; J.E. Nagtegaal 3 ; A. Wieringa 4 ; P. de Smet 5 ; G.J. van der Wilt 5 ; and C. Kramers 1,5 1 Canisius Wilhelmina hospital, Nijmegen, The Netherlands; 2 Erasmus Medical Centre, Rotterdam, The Netherlands; 3 Meander medical centre, Amersfoort, The Netherlands; 4 Isala hospitals, Zwolle, The Netherlands; and 5 Radboud University Medical Centre, Nijmegen, The Netherlands Background: Prescription errors in the hospital can lead to prevent- able harm to patients. These events are often caused by NSAIDs, anti- coagulants, diuretics, antibiotics and opioids. Especially patients on surgical departments are at risk, since patients with complex co-mor- bidities in complex situations are treated by physicians who have had no specific additional training on prescribing. The hospital pharmacist has an important role to safeguard patients for medication errors. Material and Methods: The P-REVIEW study is an open interven- tion study with a before after design that introduces a structured education program on pain management, anticoagulants, fluid and electrolyte management and antibiotics for prescribing physicians on surgical departments of large community hospitals. In addition a weekly structured medication review is performed by hospital pharmacists on high risk surgical patients and discussed with the physician (assistant) on the ward. Risk assessment is based on pain medication, anticoagulant therapy and comorbidities (for example, heart and renal failure). The aim of this intervention is to educate and support the prescribing physician on high risk patients, aimed at qualitatively improved prescribing. Also an economic evaluation was performed. Results: A total of 13,264 admissions of surgical patients were included (6780 admissions in the usual care group vs 6484 admis- sions in the intervention group). Results of the study show that this intervention leads to a significant reduction of preventable serious adverse events (disability, death, increases hospital stay and readmis- sion) due to prescription errors (106 events versus 73 events, P = 0.029). The pharmaco economic analysis shows that the intervention does not incur higher costs due to time spent by involved health-care providers (€6.04 vs €6.18 per admission, P = 0.272). Conclusion: This large study shows that education and support of the prescribing physician on high risk patients on surgical depart- ments by the hospital pharmacist leads to a significant clinical rel- evant benefit for patients. ANALGESIC DRUG CONSUMPTION INCREASES AFTER CARPAL TUNNEL SURGERY: A PHARMACOEPIDEMIOLOGICAL STUDY INVESTIGATING POSTOPERATIVE PAIN A. Palmaro 1,2 ; R. Fuzier 1,2 ; I. Serres 1,2 ; R. Bourrel 3 ; and M. Lapeyre-Mestre 1,2 1 Medical and Clinical Pharmacology Unit, CHU Toulouse University Hospital, Toulouse, France; 2 Pharmacoepidemiology Research Unit, INSERM 1027, University of Toulouse, Toulouse, France; and 3 National health insurance fund for workers. Toulouse, France Background or Introduction: The aim of this pharmacoepidemio- logical study was to investigate analgesic drug consumption before and after surgery as a surrogate of chronic postoperative pain. Material and Methods: A retrospective cohort study of French ben- eficiaries from the main health insurance scheme in Midi-Pyrenees area was designed using data from the SNIIRAM (Système National d'Information Inter-Régime de l'Assurance Maladie). All patients undergoing carpel tunnel surgery between 1 January 2010 and 30 June 2010 were identified. Definition of increase in antineuropathic drugs (carbamazepine, gabapentine, prégabaline, clomipramine, amitriptyline, duloxetine, clonazepam) or opioids (ATC code N02A) was based on the comparison of the accumulated Defined Daily Doses (DDDs) received by months between pre (2 mo before) and late postoperative period (2–12 mo after surgery). A multivari- ate logistic regression model was used to identify factors associated with increase in either antineuropathic or opioid analgesic drug consumption. Results: Among the 3495 patients included, 3082 received at least one analgesic during the late postoperative period (29%, n = 1003 for opioids and 14%; n = 499 for antineuropathics). Consumption of opi- oid analgesics was increased in the late postoperative period in 22% of the patients (n = 752) (10% (n = 359) for antineuropathics). History