Research Article Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries Yasser Osman , 1 Tarek Elsharkawy, 1 Tariq Mohammad Hashim, 1 Jumana Abdulwahab Alratroot, 1 Fatima Aljindan, 1 Liqa Almulla, 1 Hind Saleh Alsuwat, 2 Waad Mohammed Al Otaibi, 2 Fatma Mohammed Hegazi, 2 Abdallah M. Ibrahim, 2,3 J. Francis Borgio , 2 and Sayed AbdulAzeez 2 1 Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia 2 Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia 3 Department of Fundamentals of Nursing, College of Nursing, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia Correspondence should be addressed to Yasser Osman; yosman@iau.edu.sa Received 21 August 2022; Revised 20 September 2022; Accepted 30 September 2022; Published 11 October 2022 Academic Editor: Taobo Hu Copyright © 2022 Yasser Osman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9:14 × 10 -09 ) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2:05 × 10 -07 ). Although our patients’ numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries. 1. Introduction Breast cancer, as a multifactorial disease, is the most common cancer in the world [1]. The major risk factors associated with breast cancer appear to be environmental and genetic factors [2, 3]. Previous studies indicate that genetic factors account for about 27% of the breast can- cer risk [4]. A few genes including BRCA1, BRCA2, and ATM have been known to be associated with the risk of breast cancer [5]. Yang et al. reported meta-analyses, including 14306 cases and 15099 controls group numbers from 13 case- control studies, and explored the association between the rs3803662 polymorphism and the risk of breast cancer. Their results indicated that rs3803662 is significantly associ- ated with breast cancer risk in Caucasian women but did not find this association in Asian women [6]. In addition, Garcia et al. reported the association of XRCC4 c.1394G > T with breast cancer development among selected Filipinos [7]. The results by Garcia et al. supported the hypothesis that polymorphisms in the XRCC4 c.1394G > T gene may influence the functioning of the DNA repair pathway [7]. Node-like receptors (NLR) are a group of intracellular proteins that can detect microbes and abnormal signals. Thus, it could control various immune pathways. There are around 22 NLR proteins that has not been well studied [8]. NLRC5 is one of the NLR proteins which is expressed mostly in the lymphoid and myeloid cells. The expression of NLRC5 is found to have been induced strongly by INF-y [9]. Hindawi International Journal of Breast Cancer Volume 2022, Article ID 2442109, 10 pages https://doi.org/10.1155/2022/2442109