This work is licensed under a Creative Commons Attribution 4.0 International License. The license permits unrestricted use, distribution, and reproduction in any medium, on the condition that users give exact credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if they made any changes. Antiretroviral Drug Management Tool and Performance of HIV/AIDS projects in Kisumu County, Kenya: A Digital Heath Solution Approach Collins Mudogo  University of Nairobi, Kenya Angeline Mulwa University of Nairobi, Kenya Dorothy Kyalo University of Nairobi, Kenya Abstract: The aim of this study was to assess the influence of utilization of the digital health intervention for antiretroviral drug management on performance of HIV/AIDS projects in Kisumu County. An ex-post facto cross-sectional descriptive study was conducted to gain understanding on the influence of the use of the digital health intervention for antiretroviral drug management on the performance of the HIV/AIDS projects. The study was conducted in eight (2 level V and 6 level IV) health facilities providing HIV/AIDS care and treatment in Kisumu. Using a census approach the study recruited 191 participants who were health service providers across the study sites. The study used a 5-point Likert scale to measure the perspectives of the participants on aspects of utilization of the digital health intervention for antiretroviral drug management and performance of HIV/AIDS projects. A key informant interview guide was used to collect qualitative data. There was a positive significant relationship between utilization of digital health interventions for antiretroviral drug management and performance of HIV/AIDS projects with a Pearson Coefficient value=0.507, p value<0.001. A linear regression model gave an R square value of = 0.332, indicating that utilization of the digital health intervention for ARV drug management could positively influence up to 33.2% of improvement in performance of HIV/AIDS projects. This study concluded that using technology to manage drugs has potential to significantly improve overall performance of a health project. Increased investment towards scaling implementation of the Web antiretroviral dispensing tool as the commonly used intervention. Keywords: Antiretroviral Drug Management, digital health intervention, HIV/AIDS, Health project management. Introduction Considerable gains have been made towards controlling the HIV/AIDS epidemic in Africa. This is evidenced by the reducing number of new infections compared to HIV/AIDS related deaths with both new infections and deaths being on a significant decline over time an indication that there are concerted efforts to turn the HIV/AIDS tide by ending the epidemic by 2030 (Frescura L et al., 2022). People living with HIV/AIDS and are not on treatment have occurrences of higher morbidity and mortality Suggested Citation Mudogo, C., Mulwa, A. & Kyalo, D. (2023). Antiretroviral Drug Management Tool and Performance of HIV/AIDS projects in Kisumu County, Kenya: A Digital Heath Solution Approach. European Journal of Theoretical and Applied Sciences, 1(4), 608-617. DOI: 10.59324/ejtas.2023.1(4).56