International Journal of Ayurvedic Medicine, Vol 14 (1), 2023; 260-267 Published online in http://ijam.co.in ISSN No: 0976-5921 Research Article Key Words: Acne vulgaris, Kshudrarog, Khadirashtak kwath, Lep, Lodhradi lep, Mukhdushika. Introduction ‘Face is index of mind’ Among five sense organs, Skin is largest organ of body. Facial skinreflects joy, sorrow, anger and all other expressions. We can say personality of person reflects through his face. In this, present scenario, people are very much conscious about their health aswell as beauty and good looking. Skin is one of the five Gyanendriyas (sense organs) as described in Ayurvedic texts. (1) It is responsible for touch sensation, henceplays important role in Physical and Mental wellbeing. It plays the mostimportant role by interfacing with surrounding. On contrary with this thereis increased pollution, stress, change in diet, change in life style causingthe most burning skin problem i.e. Mukhdushika so called Acne Vulgaris.It affect wonder years of an individual’s life i.e. 16-30 years. People aremore beauty conscious during this age. Thisminor ailment may causepermanent disfigurement of face which may result in inferiority complexand sometimes isolation in social life. Acne vulgaris means vulgar to vision and the Mukhdushika suggests the dushan (vitiation) of Mukha (face). In most cases, Acnefirst appears at 12-14 yearsof age. According to the global burden ofdisease study (GBD), Acne vulgaris affects 85% of young adults aged 12– 25 years. Acne consistently represents the top three most prevalent skinconditions in the general population (2).Researchers have determined thatthe patient of acne had greater impairment in mental health as comparedto patients having Diabetes mellitus, Hypertension, Asthma, Joint pain,Epilepsy etc. Huge amount of money is spend to cure acne by Teenagers.The attitude towards acne varies physician to physician. Somedermatologist takes a more sympathetic stance and proactive and keen totreat the condition. Some take it very normal and helps the sufferer towait and grow out of it. Ayurveda has described Mukhdushika under Kshudrarogas (minor ailments). Thisdisease is called as Kshudrarog (3),as compared to Mahavyadhis (major illnesses) or Vyadhis (diseases).Vitiation of Kapha (factor giving lubrication and structure), Vatadosha (factor causing movement) along with Dushya Rakta (affected blood cells) give rise tosymptoms like swelling, pain, redness, itching and Shalmali kantak (Thorn of Salmalia malabarica Schott & Endl.) like appearance on the face (4). According to modern science, it causes due to Propionobacterium acne (5). Evaluation of combined efficacy of Lodhradi lep with Khadirashtakkwath in Mukhdushika Mayuri Amol Deshpande 1* , Sadhana Kulkarni 2 , Amol Madhav Deshpande 3 1. Assistant Professor, Department of Kayachikitsa, 3. Assistant Professor, Department of Rachana Sharir, Mahatma Gandhi Ayurved College and Research Centre, Datta Meghe Institute of Higher Education & Research (Deemed to be University) Salod (H), Wardha. India. 2. Professor, Department of Kayachikitsa, Radhakrishna Toshniwal Ayurved Mahavidhyalaya and Research Centre, Akola, Maharashtra, India Abstract Mukhdushika (Acne vulgaris) is burning issue among young generation. It gives inferiority complex in social life. There are lots of medicines for acne vulgaris but the results are not upto the mark. Our aim is to combat with Mukhdushika with simple herbal formulation. Randomised controlled trial is preferred for the study. Methods – Aim: To evaluate efficacy of combination of Lodhradilep and Khadirashtak kwath in management of Mukhdushika. Objectives: To study the Nidan panchak of Mukhdushika as described in Ayurveda samhita. To study the effect of combination of Lodhradi lep and Khadirashtak kwath. Randomized control trial was conducted in two arms, Group A (Lodhradilep) and Group B (Lodhradi lep with Khadirashtak kwath). 30 patients were selected randomly and Lodhradi lep was given for group A. 30 patients were selected randomly and Lodhradi lep with Khadirashtak kwath was given for group B. Result – The group B shown significant result in all the signs and symptoms. Discussion–The Z value was significant in all the objective criteria which shows Group B was more effective than group A in treating Mukhdushika. 260 * Corresponding Author: Mayuri Amol Deshpande Assistant Professor, Department of Kayachikitsa, Mahatma Gandhi Ayurved college and research centre, Datta Meghe institute of higher education & research (Deemed to be University) Salod (H), Wardha, Maharashtra. India. Email Id: mayuri.deshpande@dmimsu.edu.in