Rubavathi et al Journal of Drug Delivery & Therapeutics. 2020; 10(3-s):98-106 ISSN: 2250-1177 [98] CODEN (USA): JDDTAO Available online on 15.06.2020 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Research Article Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts Subbaiyan Rubavathi *, Ganesan Ayyappadasan, Nagarajan Sangeetha, Thangavel Harini, Dhanuskodi Saranya and Prakash Harshapradha Department of Biotechnology, K .S. Rangasamy college of Technology, Tiruchengode – 637 215, Namakkal, Tamil Nadu, India ABSTRACT Obesity is a condition in which large amount of fat is stored in adipose tissue. Obesity is the greatest risk for many diseases like coronary heart disease, type 2 diabetes millions associated with insulin resistance, arthritis disorder, hypertension and cancers. Currently, the available drugs for obesity have been associated with number of side effects when compared with allopathic drugs. Salvia hispanica was one of the member of Lamiaceae family, collected to study the antiobesity activity. Extraction of Salvia hispanica using different solvents was done and tested for the presence of phytochemical constituents and the antimicrobial activity was monitored to evaluate the zone of inhibition. Further, antioxidant potential activity such as DPPH, FRAP and H2O2 assay was studied. Percentage of inhibition of Salvia hispanica was calculated and was observed as in capturing the free radicals present in the body. The surface and cross-sectional morphology Salvia hispanica extract nanoparticles was examined by using SEM. High ALA content make chia a perfect as it is associated with lower incidence of Cardiovascular diseases. This metabolic syndrome is mediated by inflammatory pathways. Hence, the in vitro activity of anti-inflammatory assay was performed by inhibition of albumin denaturation and anti-obesity activity was performed by lipase inhibition assay. Thus the result indicates that the seed extracts of Salvia hispanica possess antiobesity activity. Keywords: Salvia hispanica, anti-obesity, cholesterol, Antioxidant, lipase inhibition Article Info: Received 26 March 2020; Review Completed 23 May 2020; Accepted 29 May 2020; Available online 15 June 2020 Cite this article as: Rubavathi S, Ayyappadasan G, Sangeetha N, Harini T, Saranya D, Harshapradha P, Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts, Journal of Drug Delivery and Therapeutics. 2020; 10(3-s):98-106 http://dx.doi.org/10.22270/jddt.v10i3-s.4169 *Address for Correspondence: Rubavathi Subbaiyan, Department of Biotechnology, K .S. Rangasamy college of Technology, Tiruchengode – 637 215, Namakkal, Tamil Nadu, India INTRODUCTION Salvia hispanica, is a biannually cultivated plant, is categorized under the family (Labiatae), super division of Spermatophyta, and kingdom of Plantae. Obesity is severe metabolic disorder in which excess body fat has accumulated in our body to the extent which may cause severe side effect on health leading to increased health problems 1 . Obesity is caused by an imbalance between energy intake and expenditure. Currently, no pharmacological treatment provides to reduce obesity with minimal side effects 2 . Chia seeds are high in phenolic compounds which have been scientifically proven to exhibit antioxidant related functions 3 . The plant seeds showed various pharmacological activities like cytotoxic, anti- inflammatory, antioxidant, antiproliferate, antimicrobial, hypolipidemic and hypoglycemic activities 4 . Chia seeds when placed in water produce a gel, this gel have good water binding capacity, oil holding capacity, viscosity and emulsion activity. Chia seeds are a good source of fatty acids, dietary fiber, protein, minerals and antioxidants. Oil extracted from chia seeds can also be used in food 3 . Chia seed are high in phenolic compounds which have been scientifically proven to exhibit antioxidant related functions. Chia is one of the highest sources for omega-3, which is essential for maintaining healthy cholesterol level, brain development, immune system and it has anti-inflammatory effect. Chia seeds are better than using herbal plants and other pharmaco drugs for Obesity. A variety of natural products, including crude extracts and isolated pure natural compounds can induce body weight reduction and prevent diet-induced obesity. Therefore, they have been widely used in treating obesity 5 . It was observed that chia seeds decrease total cholesterol level and increases LDL cholesterol. Chia seeds are a rich source of dietary fiber, which reduces the hunger sensation, and the omega-3 FA ALA, which is essential for the emulsification and absorption of the liposoluble vitamins A, D, E, and K 6 . Chia oil improved