Copyright © 2018 Mutaz B. Habal, MD. Unauthorized reproduction of this article is prohibited. Recurrence of Giant Cell Tumor of The Larynx Resit Murat Acikalin, MD,  Ays ¸e Vildan O ¨ zsan, MD,  Yalcin Alimoglu, MD,  Zafer Gezginadam, MD,  Huseyin Tarik Yanik, MD,  Samet Cagri Coskun, MD,  and Hasan Kaya, MD y Abstract: Giant cell tumor of the larynx is a rare tumor. It was first reported by Wessely et al in 1940. Thirty-nine cases have been reported until now and together with the current case 2 recurrences were encountered. In this case report, our aim was to discuss conservative management because of the suspicion of recurrence. A 70-year-old male patient was admitted to our clinic with the complaint of hoarseness. A tumor measuring 1  1 cm located in the anterior half right vocal fold and extending to the anterior comissure was found on laryngeal endoscopy. Direct laryngoscopy and biopsy of the mass revealed giant cell tumor on histopathological exami- nation. Tumor resection with cordectomy through laryngofissure and subsequently medialization thyroplasty were performed. Hor- aseness of the patient improved. On 2-year follow-up, a tumoral lesion suggesting recurrence was found on the vocal cord. Direct laryngoscopy and biopsy confirmed recurrence. Total laryngectomy was performed. This is the second case of recurrent giant cell tumor of the larynx. The therapy of choice should be selected considering the possibility of recurrence. Key Words: Giant cell tumor of the larynx, literature review, recurrence G iant cell tumor is a benign bone tumor and comprises 20% of benign bone tumors. 1 They commonly arise from the epiphysis of the long bones and are more commonly seen in women. 2,3 Giant cell tumor of the larynx is a rare tumor. The first case has been reported by Wessely et al in 1940. 4 A total of 39 cases and 2 recurrences including this case have been reported in the litera- ture. 4–22 We present a case of giant cell tumor of the larynx and review current literature. CLINICAL REPORT A 67-year-old male patient has been admitted to our clinic in April 2014 with the complaint of hoarseness. A hypertrophic and degenerated mass located in the anterior one-third of the right vocal fold and extending to the anterior commisure was found on larynx endoscopy. An enhancing nodular tumoral lesion located in the anterior half of the vocal fold and extending to the anterior comissure measuring 14  9 mm in axial sections was found in neck computed tomography (CT). There was no sign of thyroid cartilage invasion (Fig. 1A). However, the paraglottic fat planes were obscured at the level of the anterior commissure and on the anterior half of the right vocal fold. Direct laryngoscopy and biopsy revealed giant cell tumor. The patient was scheduled for cordect- omy through laryngofissure. In surgery performed in July 2014, the tumor was found to be located in the middle of the right vocal fold. Right cordectomy was performed. On histopathological examina- tion, a vascular tumor stroma containing abundant spindle cells, and many multinuclear osteoclast-like giant cells were observed (Fig. 1C). On the 5-month follow-up, an aperture of 3 to 4 mm in the rima glottis was observed. Medialization thyroplasty was performed for hoarseness. On the follow-up examination in May 2016, the patient reported worsening hoarseness. Leukoplakia and a tumoral lesion suggesting recurrence were observed in the anterior half of the left vocal fold on larynx endoscopy. Neck CT and magnetic resonance imaging (MRI) showed tumoral lesion measuring 20  14  16 mm at the level of the left vocal fold extending to the anterior comissure and causing destruction in the adjacent thyroid cartilage in its ante- rolateral part for a distance of 7 mm (Fig. 1B). The left paraglottic planes were obscured. The right paraglottic fat planes were obscured inferiorly. The tumor extended to the subglottis inferiorly in its anterior part for a distance of 4 mm. Direct laryngoscopy and biopsy were performed. Histopathological examination revealed giant cell tumor. The patient underwent total laryngctomy. The postoperative period was uneventful and oral intake was restarted on the 7th postoperative day. On histopathological examination, giant cell tumor of the larynx was observed. No tumor recurrence was seen in the follow-up period of 22 months. From the  Deptartment of Otolaryngology; and y Deptartment of Pathology, Haseki Training and Research Hospital, Istanbul, Turkey. Received January 20, 2017. Accepted for publication September 23, 2017. Address correspondence and reprint requests to Dr. Ays ¸e Vildan O ¨ zsan, Haseki Training and Research Hospital, Department of Otorhinolar- yngology, Fatih- Istanbul, Turkey; E-mail: vildanozsan@gmail.com The authors report no conflicts of interest. Copyright # 2018 by Mutaz B. Habal, MD ISSN: 1049-2275 DOI: 10.1097/SCS.0000000000004219 FIGURE 1. (A) Axial section of neck computed tomogrphy with contrast. (B) Axial section of neck magnetic resonance imaging with contrast. (C) Vascular tumor stroma containing abundant spindle cells, and many multinuclear osteoclast-like giant cells were observed. Hematoxylin and eosin staining (400 close-up view). BRIEF CLINICAL STUDIES The Journal of Craniofacial Surgery  Volume 00, Number 00, Month 2018 1