198 SUMMARY A cost comparison of warfarin vs enoxaparine or new oral anticoagulants used for the treatment of patients with pulmonary embolism Introduction: Recently, novel oral anticoagulants (rivaroxaban, dabigatran, apixaban) have been approved for pulmonary embolism (PE) treatment. Each anticoagulant used during initial and maintenance therapy has direct and indirect costs for healthcare systems. Demonstrating the costs of treatment with different anticoagulants in a specific patient group will be helpful for clinicians determining treatment strategies. Materials and Methods: Retrospective data of 118 patients with PE who were hospitalized and treated with warfarin for at least 3 months were evaluated. Direct medical and nonmedical costs were calculated. True costs with warfarin and modeled costs with rivaroxaban, dabigatran, apixaban and enoxaparine were calculated and compared for maintenance therapy. Estimated costs of initial and maintenance treatment with different anticoagulants were compared for the 49 patients with low complication risk. Results: The average total cost of maintenance treatment with warfarin was found to be higher than the novel oral anticoagulants (€286.5 for warfarin, €233.3 for rivaroxaban, €231.7 for dabigatran, and €229.6 for apixaban). In patients with low complication risk, who could be treated without hospitalization, alternative treatment regiments were found to cost less than warfarin treatment (€883.1 for warfarin, €254.3 for rivaroxaban, €238 for apixaban, and €810.6 for enoxaparine). Conclusion: Maintenance therapy with novel oral anticoagulant costs less than warfarin treatment. In patients with lower complication risks, alternative regimens that do not require hospitalization could cost less. Key words: Economics, pharmaceutical, pulmonary embolism, new oral anticoagulants ÖZET Akut pulmoner embolide varfarin ile enoksaparin veya yeni oral antikoagülanların kullanımının maliyetlerinin karşılaştırılması Giriş: Yeni nesil oral antikoagülanlar (rivaroksaban, dabigatran, apiksaban) yakın zamanda pulmoner emboli (PE) tedavisi için onay almış ilaçlardır. Başlangıç ve idame tedavisinde kullanılan A cost comparison of warfarin vs enoxaparine or new oral anticoagulants used for the treatment of patients with pulmonary embolism doi • 10.5578/tt.24153 Tuberk Toraks 2016;64(3):198-205 Geliş Tarihi/Received: 25.08.2015 • Kabul Ediliş Tarihi/Accepted: 28.03.2016 KLİNİK ÇALIŞMA RESEARCH ARTICLE Murat TÜRK 1 Yağmur ALDAĞ 2 İpek Kıvılcım OĞUZÜLGEN 2 Numan EKİM 2 1 Clinic of Chest Diseases, Yerkoy State Hospital, Yozgat, Turkey 1 Yerköy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Yozgat, Türkiye 2 Department of Chest Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey 2 Gazi Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye Dr. Murat TÜRK Yerköy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, YOZGAT - TURKEY e-mail: mrttrk@gmail.com Yazışma Adresi (Address for Correspondence)