_____________________________________________________________________________________________________ ≡ Assistant Professor; ⱷ Associate Professor; # Professor & Head; *Corresponding author; Journal of Pharmaceutical Research International 33(63B): 368-373, 2021; Article no.JPRI.80064 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Protocol for Managing Antimicrobial Activity in the Patients with Maxillary Defect by Functionalization of Silicone Using Different Nanoparticles: A Randomized Control Trial Tanvi Jaiswal a≡* , Sweta Kale (Pisulkar) aⱷ and Seema Sathe (Kambala) a# a Department of Prosthodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i63B35666 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/80064 Received 24 October 2021 Accepted 28 December 2021 Published 29 December 2021 ABSTRACT Background: Patients with facial or intraoral defects are mostly reconstructed by prosthesis for which maxillofacial silicone considered as a material of choice for better aesthetics. Silicones are widely used medical materials. One of the major problems associated with the use of maxillofacial silicone material is microorganisms and fungal growth especially Candida albicans, which can result in chronic infection, inflammation and degradation of silicone material that's why the development of antimicrobial silicone elastomer became so important. So, a multiple study is performed trying to improve this property. Nanoparticle technology is rapidly advancing and is used for a wide range of applications in medicine. The potential of metal nanoparticles as antimicrobial agents is widely studied and is considered as an alternative approach to overcome the challenge posed by multidrug resistance in bacteria. Objective: The present study aims at to evaluate compare the antimicrobial activity of different nanoparticles through functionalization of silicone in the patients with maxillary defect. Methods: A prospective interventional study will be conducted for two years. The subjects in the Study Protocol