Copyright@ CV Chandarana | Biomed J Sci & Tech Res | BJSTR. MS.ID.006768. 33714 Review Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2022.42.006768 Analytical Quality by Design: A Review for Chromatography CV Chandarana 1 *, NR Mithani 2 and PR Prajapati 3 1 Department of Pharmaceutical Quality Assurance, SSR College of Pharmacy, India 2 Smt. BNB Swaminarayan Pharmacy College, India 3 Department of Pharmaceutical Chemistry, SSR College of Pharmacy, India *Corresponding author: CV Chandarana, Assistant Professor, Department of Pharmaceutical Quality Assurance, SSR College of Pharmacy, Sayli, Silvassa- 396230, India ARTICLE INFO ABSTRACT Received: March 02, 2022 Published: March 11, 2022 Citation: CV Chandarana, NR Mithani, PR Prajapati. Analytical Quality by De- sign: A Review for Chromatography. Bi- omed J Sci & Tech Res 42(3)-2022. BJSTR. MS.ID.006768. Keywords: Analytical Quality by Design; Pharmaceuticals; HPLC; HPTLC; UPLC; UHPLC Background: In recent times, product quality has been a primary focus in the pharmaceutical industry. The quality by design (QbD) strategy contributes to higher productivity through the application of several approaches, such as process analytical technology (PAT), analytical target profiling (ATP), critical quality attribute (CQA) assessment, and quality target product profiling (QTPP) (QTPP). Objectives: To summarize the quantitative applications of HPLC, HPTLC, UPLC and UHPLC by applying Analytical Quality by Design. Methods: This article shows current quantitative applications of Analytical QbD in analytical method development like HPTLC (High-Performance Thin Layer Chromatography), HPLC (High-Performance Liquid Chromatography), UPLC (Ultra- Performance Liquid Chromatography) and UHPLC (Ultra-High-Performance Liquid Chromatography) for more than 60 drugs. Result: To demonstrate drug quality, the ICH recommendations Q8, Q9, and Q10 for pharmaceutical development, quality risk management, and pharmaceutical quality management, respectively, have been produced. Conclusion: All found methods required very less time for detection and it improves the quality by applied all analytical methods. Abbreviations: QBD: Quality by Design; PAT: Process Analytical Technology, ATP: Analytical Target Profiling, CQA: Critical Quality Attribute, QTPP: Quality Target Product Profiling; CMC: Chemical, Manufacturing, and Control; TPQP: Target Product Quality Profile; CPP: Critical Process Parameters; RPN: Risk Priority Number; HPTLC: High-Performance Thin-Layer Chromatography; HPLC: High-Performance Liquid Chromatography; UHPLC: Ultra-High-Performance Liquid Chromatography; RP-HPLC: Reversed-Phase High Performance Liquid Chromatographic Method; API: Active Pharmaceutical Ingredient Introduction to Quality by Design (QBD) The pharmaceutical industry develops a high-quality product that is both safe and efficient. Not only does QbD improve the quality of the final product, but it also improves the quality of the entire production process. Finally, the product must satisfy patient’s demands as well as experimental results [1]. Various regulatory bodies are concerned with product safety. Manufacturing costs