Molecular Characterization of Tomato Leaf Curl Disease-Causing Viruses in Uganda Ssekyewa Charles, Van Damme P. & Steele K. A. In this study, Tomato Leaf Curl Disease symptom-bearing samples were collected from dry savannah (Eastern and Northern) and wet equatorial/tall grass savannah (Central and Western) agro-climatc zones of Uganda. Their total DNA was extracted using a modified Dellaporta protocol. Virus DNA was amplified with five different primer pairs for Tomato yellow leaf curl virus (TYLCV), Tomato yellow leaf curl Sardinia virus (TYLCSV-Sic) and Tomato leaf curl Uganda virus (TLCUV) as well as their combinatons. The results indicated that there is wide variaton in the tomato leaf curl viruses in the Country. The viruses were grouped into 24 categories and three (3) distnct virus genomes, namely, Tomato leaf curl Uganda virus-Sorot, Tomato leaf curl Uganda virus- Iganga (Pallisa) and Tomato leaf curl Arusha virus-Mubende, were characterized. Partal results indicated occurrence of viruses related to TYLCV and TYLCSV-Sic in wet agro-climatc zones. Genomic variaton was detected within isolates and recombinaton was suspected. Key words: Tomato; Begomoviruses; Genome; Co-Evoluton; Recombinaton Introduction Tomato (Solanum lycoperscicum) is a fruiting vegetable. It originated in Latin America and has become one of the most widely grown vegetables, with ability to produce in diverse environmental conditions (Rice et al., 1987). The tomato fruit is fairly rich in vitamins A and C; is of high cash value; and has much potential for value-adding processing. In Uganda, about 5-30% of the farming households grow tomato, not only as a source of vitamins and food security, but also as a source of income (Ssekyewa, 2006). Tomato grows best in fertile, well-drained soils, with pH6 and ambient temperatures of about 25 0 C (Villareal, 1979; Rice et al., 1987), which are common in Uganda (Mukiibi, 2001). Thus, National Agricultural Research Organization (NARO, 1999) prioritizes it among the vegetables to be promoted in the country. With proper management practices, a smallholder commercial farmer is expected to reap at least 100t/ha (AVRDC, 1994). In Uganda, however, average yield is 10t/ha (Ssekyewa, 2006). This is due to a number of factors, including the use of unimproved varieties, occurrence of pests and diseases and ignorance about sustainable agronomical practices (Akemo et al., 2001). Caribe, Magrobe, Pakmor and Tropic tomato varieties are reported to be acceptable to farmers and consumers in Uganda while VF 6203 and Peto-C-8100 159, which have resistance to Verticilium and Fusarium, are recommended for processing (Mwaule, 1995). Mwaule (1995) and Akemo et al. (2001) also confrmed the World Vegetable Centre’s MT 40, 41, 55, 56 and 57 tomato lines to be resistant to bacterial wilt (Ralstonia solanacearum). It is also Journal of Science and Sustainable Development Copyright © 200 Uganda Martyrs University ISSN: 200-1; Vol 2 (1): 11—22 www.umu.ac.ug