1 National Journal of Physiology, Pharmacy and Pharmacology 2022 | Vol 12 | Issue 05 (Online First) RESEARCH ARTICLE Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile Ankita Chaturvedi 1 , Arvind Kumar Pal 2 , Khushboo Singhal 3 , Narsingh Verma 1 1 Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India, 2 Department of Physiology, Autonomous State Medical College, Firozabad, Uttar Pradesh, India, 3 Department of Physiology, University College of Medical Science GTB Hospital, New Delhi, India Correspondence to: Arvind Kumar Pal, E-mail: avineet2008@rediffmail.com Received: October 05, 2021; Accepted: November 02, 2021 ABSTRACT Background: Abdominal obesity is associated with insulin resistance, in turn, hyperinsulinemia and visceral adiposity lead to an increased uric acid (UA) absorption in renal tubules. Aim and Objectives: Accumulation of visceral fat is an underlying component of metabolic syndrome. Furthermore, the waist-hip ratio is an indirect tool for assessing visceral fat. The present study evaluates the association of UA levels with the waist-hip ratio. Materials and Methods: 160 subjects aged 18–60 years were enrolled in the study (those having any anatomical deformity, diabetes, and/or hypertension for more than 5 years were excluded from the study). Their anthropometric parameters, blood pressure, lipid profile, fasting plasma glucose, and serum UA levels were measured. Results: The study population was divided into three groups based on UA levels. The waist-hip ratio in a group of the hyperuricemic population was more as compared to groups of normal and below normal UA levels population and the association of UA level with waist-hip ratio was found to be significant (P = 0.045). Conclusion: The over-inflow of free fatty acid to the liver from accumulated visceral fat may be linked to the de novo purine synthesis through the pentose phosphate pathway, which may accelerate the production of UA. KEY WORDS: Waist-hip Ratio; Serum Uric Acid; Visceral Fat INTRODUCTION The syndrome X/metabolic syndrome is a group of risk factors for cardiovascular disease (CVD), including obesity, hypertension, elevated triglycerides, and low levels of high- density lipoprotein cholesterol (HDL-C). The metabolic syndrome includes high blood pressure, hyperglycemia, abdominal obesity, hypertriglyceridemia, and decreased HDL-C. Access this article online Website: www.njppp.com Quick Response code DOI: 10.5455/njppp.2022.12.10386202102112021 National Journal of Physiology, Pharmacy and Pharmacology Online 2022. © 2022 Arvind Kumar Pal, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. Based on the population and definitions used, [1] the preponderance of this syndrome is 18% in women and 8–13% in men. Metabolic syndrome has been recognized as one of the highest prevailing problem in many countries worldwide. [2-4] Visceral adiposity is believed to be the main cause of the cardio vascular risk leading to syndrome of insulin resistance/central obesity. In accordance with International Diabetes Federation [5] or National Cholesterol Education Program-Adult Treatment Panel-III, clinical definitions of metabolic syndrome have been of enormous worth in the diagnosis, control, and research on various metabolic risk factors. Although, there are evidences suggesting other pro- thrombotic, inflammatory, and atherogenic characteristics of the syndrome which are not expressed by these clinical definitions and need further investigation, specifically for useful clinical markers. [6] National Journal of Physiology, Pharmacy and Pharmacology