Human Health Issues due to Aflatoxins Exposure and its Management LGU. J. Life Sci 7(2): LGUJLS MS.ID- 174 (2023) 156 LGU Journal of LIFE SCIENCES LGU Society of Life Sciences DOI: https://doi.org/10.54692/lgujls.2023.0702258 Review Article LGU J. Life. Sci Vol 7 Issue 2 April - June 2023 ISSN 2519-9404 eISSN 2521-0130 Impact of Aflatoxins Exposure on Human Health and its Management Strategies Naseem Zahra 1 *, Muhammad Hassan Raza 2 , Faheem Hafeez 3 , Muhammad Khalid Saeed 1 , Sabaz Ali Khan 2 , Asma Saeed 1 , Khurram Shahzad 1 1. Food and Biotechnology Research Centre, PCSIR Laboratories Complex, Ferozepur Road, Lahore-54600, Pakistan 2. Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, KPK, Pakistan 3. Superior College Kamoke Campus, Mari Road Adnan Garden Kamoke *Corresponding Author’s Email: drnaseemzahra@gmail.com, faheemhafeez381@gmail.com ABSTRACT: Aflatoxins are common contaminants in human food supplies that affects the world's developing economies. These are cosmopolitan in distribution and found everywhere in nature and can grow under drought, warm, and humid conditions. The aflatoxins are secondary metabolites and mostly found in feed and food products. These are oncogenic, mutagenic, and immunosuppressive in nature. On the basis of the aflatoxin producing fungi, the aflatoxins are roughly split into two distinct groups: those that penetrate in pre-harvest circumstances and those that are generated in post-harvest conditions. Aflatoxins exposure has great public health impact in economically developing nations and lot of research is taking place to reduce its harmful impacts; as a result, we need to establish preventive strategies that are feasible for these high-risk populations. This review provides in-depth information regarding the presence of aflatoxins, their analysis, and potentially harmful consequences on human health, as well as various detoxification approaches. Keyword: Aflatoxin, toxic, ELISA, detection, prevention, detoxification