This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ALL.14139 This article is protected by copyright. All rights reserved DR. ULRIKA KÄCK (Orcid ID : 0000-0003-4580-3571) DR. HANS GRÖNLUND (Orcid ID : 0000-0003-4882-7624) PROF. MARIANNE VAN HAGE (Orcid ID : 0000-0003-3091-1596) Article type : Letter to the Editor Corresponding author email id: ulrika.kack@sll.se MAIN TEXT FILE: Letter to the editor TITLE: Basophil activation testing, IgG and IgG4 in the diagnosis of dog allergy in children with and without a dog at home To the editor: Diagnosis of dog allergy in children relies mainly on clinical history and the presence of IgE- antibodies (IgE) against dog dander. In recent years, refined molecular diagnostics has enabled the analysis of IgE against specific dog allergen molecules. However, asymptomatic sensitization is common and there is still a need for more specific diagnostic tools (1). A nasal provocation test (NPT) can reproduce an allergic reaction in the nose under standardized and controlled conditions but is rarely performed in clinical settings (2). Consequently, in vitro allergen testing such as the basophil activation test (BAT) could be an attractive alternative to reflect in vivo responses to dog allergen exposure. Basophil allergen threshold sensitivity, CD- Accepted Article