Research Article Predictors of HIV/AIDS Related Ocular Manifestations among HIV/AIDS Patients in Felege Hiwot Referral Hospital, Northwest Ethiopia Guadie Sharew 1 and Muluken Azage 2 1 Department of Ophthalmology, College of Medicine and Health Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia 2 Department of Public Health, College of Medicine and Health Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia Correspondence should be addressed to Muluken Azage; mulukenag@yahoo.com Received 12 March 2015; Revised 17 April 2015; Accepted 19 April 2015 Academic Editor: Van C. Lansingh Copyright © 2015 G. Sharew and M. Azage. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Ocular manifestations in people living with HIV/AIDS are varied and afect almost all the structures of eye leading to visual impairment or blindness. Terefore, the aim of this study was to identify the predictors of HIV related ocular manifestation among ART clinic clients. Methods. Institution based cross-sectional study was employed among ART clients at Felege Hiwot referral hospital, northwest Ethiopia. Te study was conducted from 1 January 2013 to 30 January 2013. A total of 369 systematically and randomly selected clients were included in the study. Data were collected using structured questionnaires and ophthalmologic clinical examination. Data were entered and analyzed using SPSS version 16.0. Binary and multivariable logistic regression analyses were computed to identify independent predictors of HIV related ocular manifestation. Results. Twenty-fve percent (25.7%) of HIV patients had ocular manifestations. Te three most frequent signs were Squamoid Conjuctival growth (26.9%), ophthalmic herpes zoster (22.1%), and Bacterial Conjuctivitis (17.2%). History of eye problem, CD 4 count, and visual acuity of the eye were the predictors of HIV related ocular manifestation. Conclusion. In this study, a higher proportion of ocular manifestations were detected in HIV/AIDS patients. Visual acuity and CD 4 counts were the independent predictors of ocular manifestations. Tis fnding gives an insight for policy makers and concerned body to integrate ophthalmic examination in ART clinics to improve the health condition of HIV/ADIS patients. 1. Introduction Ocular manifestations among people living with Hu- man Immunodefciency Virus (HIV)/Acquired Immunode- fciency Syndrome (AIDS) are varied and afect almost all the structures of the eye. Approximately 70–80% of HIV- infected patients are expected and treated for HIV related eye disorder during the course of their illness [1]. Te life time risk of having at least one abnormal ocular lesion among HIV patients ranges from 52% to 100% [2–4]. Sub-Saharan African (SSA) countries are disproportionately hit by the virus accounting for the largest burden of HIV/AIDS; by 2008, about 22.4 million (20.8–24.1) people were living in the region [5]. Ethiopia is one of those countries afected by HIV with 1.4% of its more than 80 million population infected with HIV [6]. HIV afects the immune system that the virus can either directly infict damage to the organs of the body by itself and/or make the organs vulnerable to many opportunistic pathogens and diseases. Tere are wide arrays of diseases afecting the eyes of people living with HIV/AIDS that can occur at any time along the natural course of the disease. HIV related ophthalmic disorders occur due to several causes like opportunistic infections, vascular abnormalities, neoplasm, and drug induced and neuroophthalmic lesions. Among them, opportunistic infections are the major cause of morbid- ity and the most devastating ophthalmic disorder in people with AIDS [7, 8]. HIV-cytomegalovirus (CMV) coinfection occurs in 75–85% of patients, more than half of which develop CMV retinitis which is vision threatening. Despite this high incidence, difculties concerning the therapeutic approach and the result are relatively unsatisfactory even with Hindawi Publishing Corporation Journal of Ophthalmology Volume 2015, Article ID 965627, 7 pages http://dx.doi.org/10.1155/2015/965627