_____________________________________________________________________________________________________ *Corresponding author: E-mail: ngwuoe@yahoo.com; International Journal of Plant & Soil Science 29(2): 1-6, 2019; Article no.IJPSS.45068 ISSN: 2320-7035 A Comparative Evaluation of Selected Medicinal Plants on Male Fertility Indices (Reproductive Hormones and Sperm Profile) of Albino Wistar Rats: An Animal Case Study Oliver E. Ngwu 1* and J. I. Okoye 1 1 Department of Agronomy and Ecological Management, Faculty of Agriculture and Natural Resources Management, Enugu State University of Science and Technology, Nigeria. Authors’ contributions This work was carried out in collaboration between both authors. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/IJPSS/2019/v29i230138 Editor(s): (1) Prof. Junhong Bai, School of Environment, Beijing Normal University, Beijing, China. (2) Dr. Omer Kilic, Bingol University, Turkey. Reviewers: (1) Idiongo Okon Umoh, St. Francis University College of Health and Allied Sciences, Tanzania. (2) Tchoffo Herve, University of Dschang, Cameroon. (3) Noor Hashida Hashim, University of Malaya, Malaysia. (4) Amal Attia El-Morsy Ibrahim, Ain Shams University, Egypt. Complete Peer review History: http://www.sdiarticle3.com/review-history/45068 Received 28 October 2018 Accepted 07 January 2019 Published 06 August 2019 ABSTRACT The study aims to investigate the effects of the medicinal plants {seeds} on the reproductive hormones and sperm profile of male albino rats to ascertain their possible usefulness as fertility agent. Walnuts [Tetracarpidium conophorum], Sesame (Sesamine indicum), and Velvet bean (Mucuna pruriens) seeds were obtained and taken to the Department of plant Science and Biotechnology, University of Nigeria, Nsukka (UNN). The seeds were milled into fine powder. One hundred and ten sexually matured aibino rats of about twelve weeks weighing 130-180 g were divided into eleven groups (1-11) using completely randomized design. There were two different control groups and rats in group 1 served as the Control 1 and were fed with normal commercial feed. Rats in group 2 were administered with a drug (Ketoconazole) to induce infertility. The Infertility Induced groups were treated with low dose (groups 3-5), medium dose (groups 6-8) and Original Research Article