Objectives: In recognition of the considerable risk and impairment associ- ated with elevated symptoms of depression in adolescence, there has been a call for an increase in the indicated preventive intervention research. Based on the need for innovative prevention programs for depression and the benefits of providing these programs in schools, we developed a school- based preventive intervention program called Interpersonal Psychotherapy- Adolescent Skills Training (IPT-AST). This presentation will provide an overview of the goals, components, and techniques of IPT-AST and will summarize results from three randomized clinical trials of IPT-AST that have been implemented in schools. Methods: Studies 1 and 2 compared IPT-AST to usual school counseling for adolescents with elevated symptoms of depression. Study 3 compared IPT- AST delivered by research personnel to group counseling delivered by school counselors. Findings on depression symptoms, depression diagnoses, overall functioning, and anxiety symptoms from these three studies will be reported. Results: There is evidence that IPT-AST is effective at reducing depressive symptoms and improving overall functioning. IPT-AST may also be effective at reducing the risk of depression onset. Although IPT-AST was developed initially as a depression prevention program, IPT-AST results in significant reduction in anxiety symptoms and broadband internalizing problems, sug- gesting a transdiagnostic impact. Conclusions: IPT-AST is a promising depression prevention program, with growing evidence of efficacy. The presentation will conclude with areas for future direction. ADOL DDD PRE Supported by NIMH Grants K23 MH071320, R01 MH087481, and NARSAD Young Investigator Award http://dx.doi.org/10.1016/j.jaac.2016.07.584 25.3 FAMILY-BASED INTERPERSONAL PSYCHOTHERAPY FOR DEPRESSED PREADOLESCENTS: DEVELOPMENTAL ADAPTATIONS TO INTERPERSONAL PSYCHOTHERAPY FOR DEPRESSED ADOLESCENTS Laura J. Dietz, Psychology, University of Pittsburgh Johnstown, 450 Schoolhouse Road, 210F Krebs Hall, Johnstown, PA 15904; Rebecca Weinberg, PhD; Laura Mufson, PhD Objectives: Preadolescent depression (ages 8–12 years) is a “gateway” condition that increases the risk for recurrent depression into adolescence and adulthood, particularly when there is a strong family loading for depression. Depressed preadolescents experience marked interpersonal impairment compared to normal or psychiatric control subjects and continue to experience significantly more difficulties in interpersonal relationships with parents and peers than nondepressed control subjects, even after their symptoms remit. To date, there have been no large-scale efficacy studies comparing psychosocial treatments for preadolescent depression; hence, no “efficacious” treatments have been identi- fied for this high risk group. Family-based interpersonal psychotherapy (FB-IPT) is a developmental adaptation of interpersonal psychotherapy for adolescents (IPT- A) with depression that focuses on the family environment as a primary source of interpersonal stress for depressed preadolescents. FB-IPT provides a framework to address both interpersonal impairment in depressed preadolescents and family risk factors that may sustain their symptoms of depression. Methods: The aims of this session are to do as follows: 1) describe the development of FB-IPT with a sample group of preadolescents (ages 7–12 years) presenting for outpatient treatment for depression; and 2) present ef- ficacy data from a preliminary RCT of FB-IPT and child-centered therapy (CCT). Results: Evidence supports the efficacy of FB-IPT in increasing rates of depression remission, as well as reducing depressive symptoms, comorbid anxiety symptoms, and interpersonal impairment. Decreases in pre- adolescents’ social impairment from pre- to posttreatment are associated with preadolescents’ posttreatment of depressive symptoms. Decreased social impairment has been shown to account for the association between the FB-IPT and improved depressive symptoms in preadolescents. Conclusions: FB-IPT is an effective treatment for preadolescent depression and a promising treatment modality for broad-based internalizing symptoms in children. SAC Supported by NIMH Grant K23 MH079353 http://dx.doi.org/10.1016/j.jaac.2016.07.585 25.4 AN ADAPTIVE TREATMENT STRATEGY FOR ADOLESCENT DEPRESSION: BEGINNING WITH NBSP; INTERPERSONAL PSYCHOTHERAPY FOR DEPRESSED ADOLESCENTS Meredith Gunlicks-Stoessel, PhD, Psychiatry, University of Minnesota, F256/2B, West 2450 Riverside Ave, Minneapolis, MN 55454; Laura Mufson, PhD; Ana Westervelt, BA; Daniel Almirall, PhD; Susan Murphy, PhD Objectives: This presentation will describe a model and rationale for the development of an adaptive treatment strategy (ATS) for depression in ad- olescents. ATSs provide empirical guidelines for sequential clinical decision- making by providing decision rules that recommend when, how, and for whom treatments should be applied. These decision rules lead to person- alized treatment sequences. We will describe the development and pre- liminary evaluation of four ATSs that aim to address the following two questions that arise when personalizing treatment for adolescents who begin treatment with interpersonal psychotherapy (IPT)-A: 1) at what time point should therapists make the determination that the adolescent is not likely to respond if the initial treatment plan is continued; and 2) should the therapist increase the number of IPT-A sessions or add pharmacotherapy (fluoxetine) for adolescents who may need their treatment augmented. Methods: A 16-week pilot sequential multiple assignment randomized trial (SMART) was conducted with 40 adolescents who had a diagnosis of MDD, dysthymic disorder, or depressive disorder NOS. Data on the feasibility and acceptability of the study and treatment procedures and treatment response rates were collected. Results: Week 4 was the more feasible and acceptable decision point for assessing the need for a change in treatment. Adolescents, parents, and therapists reported a range of attitudes about medication and more inten- sive therapy as treatment options. Conclusions: The results of pilot study support the continued clinical importance of examining the efficacy of adaptive treatments for adolescent depression. The ATSs, including the week 4 decision point, showed promise in terms of their feasibility and acceptability. Experiences from the pilot study have led to improvements in how the ATSs are discussed with families and how they are implemented. These will be discussed in the presentation. ADOL DDD TREAT Supported by NIMH Grant K23 MH090216 http://dx.doi.org/10.1016/j.jaac.2016.07.586 CLINICAL PERSPECTIVES 26 LIFE MEMBERS WISDOM: CLINICAL PERSPECTIVES ON INTEGRATED CARE, HEALTH, RESILIENCE, AND THE FUTURE OF CHILD AND ADOLESCENT PSYCHIATRY Douglas A. Kramer, MD, MS, Psychiatry, University of Wisconsin School of Medicine and Public Health, 5621 Sedgemeadow Road, Middleton, WI 53562-1256; Marilyn B. Benoit, MD; Warren Y.K. Ng, MD Objectives: The objective of this Clinical Perspectives program is to 1) define integrated care; 2) explore models of integrated care; 3) present clinical ex- amples of integrated care; 4) review the role of the family in the integrated care of children and adolescents; 5) describe the similarities and differences between integrated care, collaborative care, consultation-liaison relation- ships, and public health practice; and 6) discuss access issues, barriers, advantages, disadvantages, and possible unintended consequences of providing mental health care in primary care settings. Methods: Dr. Kramer will introduce the topic of integrated care. The pre- sentations include: 1) Dr. Fritz will review the literature on integrated care JOURNAL OF THE AMERICAN ACADEMY OF CHILD &ADOLESCENT PSYCHIATRY VOLUME 55 NUMBER 10S OCTOBER 2016 www.jaacap.org S39 CLINICAL PERSPECTIVES 25.3 – 26.0