Clinical Study Long-Term Outcomes of Cultivated Limbal Epithelial Transplantation: Evaluation and Comparison of Results in Children and Adults Anita Ganger, 1 M. Vanathi, 1 Sujata Mohanty, 2 and Radhika Tandon 1 1 Cornea, Refractive and Ocular Surface Rehabilitation Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India 2 Centre of Excellence for Stem Cell Research, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India Correspondence should be addressed to Sujata Mohanty; drmohantysujata@gmail.com and Radhika Tandon; radhika tan@yahoo.com Received 20 July 2015; Revised 25 October 2015; Accepted 4 November 2015 Academic Editor: Mohit Parekh Copyright © 2015 Anita Ganger et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To compare the long-term clinical outcomes of cultivated limbal epithelial transplantation (CLET) in children and adults with limbal stem cell defciency. Design. Retrospective case series. Methods. Case records of patients with limbal stem cell defciency (LSCD) who underwent CLET from April 2004 to December 2014 were studied. Outcome measures were compared in terms of anatomical success and visual improvement. Parameters for total anatomical success were avascular, epithelized, and clinically stable corneal surface without conjunctivalization, whereas partial anatomical success was considered when mild vascularization (sparing centre of cornea) and mild conjunctivalization were noted along with complete epithelization. Results. A total of 62 cases underwent the CLET procedure: 38 (61.3%) were children and 24 (38.7%) were adults. Patients with unilateral LSCD (33 children and 21 adults) had autografs and those with bilateral LSCD (5 children and 3 adults) had allografs. Amongst the 54 autografs partial and total anatomical success were noted in 21.2% and 66.6% children, respectively, and 19.0% and 80.9% in adults, respectively ( value 0.23). Visual improvement of 1 line and ≥2 lines was seen in 57.5% and 21.2% children, respectively, and 38% and 38% in adults, respectively ( value 0.31). Conclusion. Cultivated limbal epithelial transplantation gives good long-term results in patients with LSCD and the outcomes are comparable in children and adults. 1. Introduction Te cornea is the most important part of ocular surface which provides eye with two-thirds of its focusing power and protection of ocular integrity and helps in maintaining clear and useful vision due to its transparent and avascular nature [1]. Corneal stem cells play important anti-infammatory as well as antiangiogenic roles in maintaining a normal corneal microenvironment and destruction of which leads to limbal stem cell defciency [2]. Two major associations of primary limbal stem cell defciency are aniridia and ectodermal dys- plasia. For secondary or acquired limbal stem cells defciency physical, chemical, thermal, and immunological insults are the major factors out of which chemical injuries contribute the maximum [3]. A number of therapeutic strategies for the treatment of LSCD have been documented in the past, but the decision for choosing a particular treatment modality depends solely on the severity and laterality of defciency [4, 5]. In limbal stem cell defciency as well as in other ocular pathologies, the ocular infammatory response to any kind of insult is always expected to be more in the paediatric age group [6]. In most of the published literature the success rates of CLET have been documented in adult patients, except one study where the surgical outcomes of CLET were reported in paediatric age group only [7]. The present study was hence undertaken to compare the long-term results of cultivated limbal epithelial transplant in children versus adult patients, which has not been documented yet. Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 480983, 6 pages http://dx.doi.org/10.1155/2015/480983