Turkiye Klinikleri J Case Rep. 2022;30(3):208-12 208 Secretory carcinoma (SC) is a newly described malignancy of the salivary gland, which is very sim- ilar in many features to secretary carcinoma of the breast. It is more common in elderly patients. 1-3 SC can be seen in different parts like salivary glands, breast, and lung. 4 When it is originated from salivary glands, patients usually present with painless lump. 5 It is caused by a recently described translocation that results in the ETV6-NTRK3 fusion gene. Fluores- cence in situ hybridization (FISH) and polymerase chain reaction (PCR) reverse transcription-PCR (RT- PCR) technique is currently acknowledged as the “gold standard” for the diagnosis. 1,4 Although there is no specific immune marker for the diagnosis, some immune markers can be used to exclude the most common differential diagnosis of this entity. 2 Since a large number of cases have not yet been described in the literature, the prognosis of the malignancy can- not be clarified yet. 6 With this case report, we aimed to share the cyto-histopathological and immunohistochemical properties of the newly defined malignancy. Cyto- logical diagnosis can sometimes be challenging so is the other types of salivary gland neoplasms. As in our case, specific morphological features may have con- tributed to the literature in cases where molecular techniques cannot be used. CASE REPORT A 23-year-old male patient with no previous history of any diseases was admitted with complaints of swelling and pain on the left parotid gland. Physical examination revealed a firm mass on the left parotid Fine Needle Aspiration Cytology of Secretory Carcinoma of the Parotid Gland in a Young Patient İrem Şahver İŞGÖR a , Necati ENVER b , Leyla CİNEL c a Department of Pathology, Ege University Faculty of Medicine, İzmir, Türkiye b Department of Ear Nose Throat Diseases, Marmara University Faculty of Medicine, İstanbul, Türkiye c Department of Pathology, Marmara University Faculty of Medicine, İstanbul, Türkiye This case report was presented as a poster in 41 st European Congress of the Cytology, June 10-13, 2018, Madrid, Spain. ABSTRACT Secretory carcinoma (SC) is a rare recently described entity that has characteristics similar to those of secretory breast carcinoma. We report a case of a 23 years old male with a swelling on the parotid gland. The ultrasonography guided fine needle aspiration cytology was performed on mass. Cytologically, the background of the aspirate is composed of inflammatory cells admixed with mucinous material. There were isolated cells as much as loosely cohesive clusters making papillary follicle-like glands with eosinophilic material in the lumen. Tumor cells were medium-sized round shape and eccentric nuclei with prominent nucleoli, remarkably vacuolated cytoplasm. The parotidectomy was per- formed and the pathology report revealed a SC. Histologically, the tumor is composed of microcystic, follicular, and micropapillary areas. The cytoplasm is usually vacuolated with also clear eosinophilic appearance. Immunohistochemically, tumor cells labeled with S100, MUC-4. At 5 years, the patient is disease-free and under regular follow-up. Keywords: Secretory carcinoma; MUC-4; cytology; S100; salivary gland DOI: 10.5336/caserep.2022-88919 CASE REPORT Correspondence: İrem Şahver İŞGÖR Department of Pathology, Ege University Faculty of Medicine, İzmir, Türkiye E-mail: iremisgor@hotmail.com Peer review under responsibility of Turkiye Klinikleri Journal of Case Reports. Received: 13 Feb 2022 Received in revised form: 25 Apr 2022 Accepted: 09 May 2022 Available online: 16 May 2022 2147-9291 / Copyright © 2022 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Turkiye Klinikleri Journal of Internal Medicine Türkiye Klinikleri Journal of Case Reports