Original article Duodenal Adenocarcinoma: Surgical Results of 27 Patients Treated at a Single Center § Josefina Lo ´ pez-Domı ´nguez, a Juli Busquets, a, * Lluis Secanella, a Nuria Pela ´ ez, a Teresa Serrano, b Juan Fabregat a a Unidad de Cirugı ´a Hepatobiliar y Pancrea ´ tica, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain b Servicio de Anatomı´a Patolo ´ gica, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain c i r e s p . 2 0 1 9 ; 9 7 ( 9 ) : 5 2 3 – 5 3 0 article info Article history: Received 12 February 2019 Accepted 26 June 2019 Available online 15 November 2019 Keywords: Duodenal adenocarcinoma Pancreaticoduodenectomy Segmental duodenal resection a b s t r a c t Introduction: Duodenal adenocarcinoma is a rare malignancy. Given the rarity of the disease, there is limited data related to resection results. The objective is to analyze results at our hospital after the curative resection of duodenal adenocarcinoma (DA). Material and methods: The variables were retrospectively collected from patients operated on between 1990 and 2017 at our hospital. Results: A total of 27 patients were treated. Twenty-three patients (85%) underwent pancrea- ticoduodenectomy, and 4 patients (15%) with tumors located in the third and fourth portions of the duodenum underwent segmental duodenal resection. The overall postoperative morbidity was 63% (17 patients). Postoperative mortality was 7% (2 patients); however, postoperative mortality related to surgery was 4% (1 patient). All patients had negative resection margins. A median of 18 lymph nodes (range, 0–38) were retrieved and evaluated, with a median of 1 involved node (range, 0–8). Median follow up was 23 (9–69.7) months. Actuarial overall survival was 62.2 (25.2–99.1) months. Actuarial disease-free survival was 49 (0–133) months. Conclusions: The surgical treatment of duodenal adenocarcinoma is associated with a high morbidity, although it achieves considerable survival. Depending on the tumor location and if there is no pancreatic infiltration, segmental duodenal resection with negative margins is an alternative to cephalic pancreaticoduodenectomy. # 2019 AEC. Published by Elsevier Espan ˜ a, S.L.U. All rights reserved. Adenocarcinoma duodenal: resultados del tratamiento quiru ´ rgico de una serie unice ´ ntrica de 27 pacientes Palabras clave: Adenocarcinoma duodenal Duodenopancreatectomı´a cefa ´ lica Duodenectomı´a r e s u m e n Introduccio´n: El adenocarcinoma de duodeno es una neoplasia poco frecuente, sobre la que existen pocas experiencias publicadas de los resultados tras su reseccio ´ n. El objetivo es analizar los resultados obtenidos en nuestro centro tras la reseccio ´n curativa del adeno- carcinoma duodenal (AD). § Please cite this article as: Lo ´pez-Domı´nguez J, Busquets J, Secanella L, Pela ´ ez N, Serrano T, Fabregat J. Adenocarcinoma duodenal: resultados del tratamiento quiru ´ rgico de una serie unice ´ ntrica de 27 pacientes Cir Esp. 2019;97:523–530. * Corresponding author. E-mail address: jbusquets@bellvitgehospital.cat (J. Busquets). CIRUGI ´ A ESPAN ˜ OLA www.elsevier.es/cirugia 2173-5077/ # 2019 AEC. Published by Elsevier Espan ˜ a, S.L.U. All rights reserved.