This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/lam.13432 This article is protected by copyright. All rights reserved DR. SILVIA GUZMÁN-BELTRÁN (Orcid ID : 0000-0002-7491-1910) Article type : Original Article Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae, and M. smegmatis. Running headline: Loperamide kills mycobacteria Omar M. Barrientos a , Esmeralda Juárez a , Yolanda Gonzalez a , Diego A. Castro-Villeda a , Martha Torres b and Silvia Guzmán-Beltrán a * Affiliation: a Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080. México City, México. b Subdireccion de investigación, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080. México City, México. *Correspondence: sguzman@iner.gob.mx. Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. México City, México. Significance and impact of the study Accepted Article