How to Cite: Nuaimi, B. N., Al-Taee, A. F., & AL-Kattan, M. M. (2022). The effect of Entomoeba gingivalis infection in patients with diabetes and high pressure on the level of Malonaldehyde and Glutathione. International Journal of Health Sciences, 6(S3), 6143– 6152. https://doi.org/10.53730/ijhs.v6nS3.7347 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 March 2022, Manuscript revised: 18 April 2022, Accepted for publication: 1 May 2022 6143 The effect of Entomoeba gingivalis infection in patients with diabetes and high pressure on the level of Malonaldehyde and Glutathione Ban Nzar Nuaimi Basic Dental Sciences Branch, College of Dentistry, University of Mosul Email: bannazar@uomosul.edu.iq Ahlam Fathi Al-Taee Department of Microbiology, College of Veterinary Medicine, University of Mosul, Iraq Email: ahlamaltaee@uomosul.edu.iq Muntaha M. AL-Kattan Department of biology, College of Science, University of Mosul Email: muntsbio17@uomosul.edu.iq Abstract---The current study was conducted on the Entamoeba gingivalis parasite, where only 65 females samples were collected in the form of swabs from the periodontal pocket from the subjects visiting the periodontal branch of the Teaching Hospital of the Faculty of Dentistry of the College of Dentistry / University of Mosul during the period from 12/1/2019 to 1/12/2020. Among 59 samples of females with gum disease and 16 samples from healthy feamle without gum disease, the total infection rate of the amoeba parasite for males was 69.14%, distributed among males with gum disease, where the infection rate was 73.84% and among males without gum disease 50%. A number of biochemical tests were performed on males with gum disease and some of them had hypertension and diabetes, and included measuring the concentration of glutathione (GSH), as well as measuring the of Malone didehyde (MDA) in the serum of females. An decrease in the level of the glutathione and a increase in the level of MDA were observed in the group of females with chronic periodontitis compared with the rest of the groups, as well as increase in the level of MDA in both the hypertensive and diabetic group compared to the control group at 0.05 (p) likelihood level. p ≦0.05). Keywords---entamoeba gingivalis, glutathione, Malone didehyde, GSH, MDA.