Miscellaneous Serum vitamin D level and carotid artery intima-media thickness in CVA infarct patients as a marker of atherosclerosis Rohit Rai *, A. Lalchandani, Vivudh Singh, Senthilraj, M. Godara, A. Ranjan, Ashish Kumar, P. Singh, Arvind Kumar PG Institute of Medicine, GSVM Medical College, Kanpur, India Background: To investigate the relation between serum vit D level and carotid artery IMT in CVA infarct patients as a marker of atherosclerosis. Methods: 200 patients with CVA infarct were selected for analysis between ages 45 and 80 yrs admitted to LLR Hospital Kanpur from January 2014 to June 2015. Measurements of serum vitamin D concentration and Carotid-IMT were made by elec- trochemiluminescence immunoassay and B-mode ultrasound, respectively. Confounding variables like diabetes, hypertension, smoking, alco- hol, tobacco, dyslipidemia, BMI, CRP, S. Uric acid, duration of sunlight exposure, prior history of drug intake or fracture, S Calcium, Phosph and PTH levels were considered and 200 age and sex matched controls were analysed. Data source: Questionnaires. Research technique: Multiple linear regression analysis, Correlation analysis. Results: The mean serum level of vit D was 15.36  5.08 SDng/mL and average IMT was 0.78  .08 SD mm. with Pearson coefficient of (0.7) significant at 0.01 level. The R 2 value is 0.629 with standard error of 0.056. The value of Beta for vit D to Carotid IMT was 0.592 with 0.001 level of significance. The value of Beta for HBA1c to Carotid IMT was 0.307 with 0.17 level of significance. The value of Beta for Systolic BP to Carotid IMT was 0.313 with 0.19 level of significance. The value of Beta for triglycerides to Carotid IMT was 0.195 with 0.45 level of significance. In control patients mean serum level of vit D was 25.13  3.01 SD ng/ml and average IMT was 0.44  0.09 SD mm. with Pearson coefficient of (0.36). Conclusions: Correlation analysis found an inverse relationship between serum Vitamin D level and Carotid-IMT with Pearson coefficient of (0.7) significant at 0.01 level in CVA infarct patients and correlated as a marker of atherosclerosis. There was direct relationship between HBA1c and Carotid IMT, Systolic BP and Carotid IMT and Serum Triglycerides and Carotid IMT. Therefore it is imp to maintain normal levels of Vit D, HbA1C, Sys BP, and S Triglyceride to retard athero- sclerosis. Echocardiography in normotensive diabetic patients Abhijeet Ranjan *, A. Lalchandani, Vivudh Singh, Rohit Rai, Senthilraj, M. Godara, Ashish Kumar, P. Singh, Arvind Kumar PG Institute of Medicine, GSVM Medical College, Kanpur, India Background: To study the: 1. The left ventricular systolic and diastolic dysfunction in normotensive diabetics. 2. The correlation between left ventricular dysfunction and duration of diabetes and between diabetic nephropathy and LV dysfunction. Methods: Inclusion criteria: 1. Age more than 21 years. 2. Normotensive asymptomatic diabetics with HbA1c ≥ 6.5%; FPG > 126 mg/dl; 2 h PPG > 200 or RBS > 200 mg/dl with symp- toms of hyperglycemia. Exclusion criteria: 1. Patients with hypertension, CKD, thyroid disorders, autonomic neuropathy, CHF and CAD, CLD, malignancy. Following investigations were done: a. CBC, KFT, FBS, PPBS, LFT, LipidProfile, Thyroid Profile, HbA1c. b. Chest X ray, ECG, Urineexamination, Fundus, microalbumi- nuria. c. Echocardiography. Results: (1) Majority of patients had uncontrolled diabetes with mean HbA1c 8.9%. (2) Majority of patients had increased cholesterol with mean 239.44 mg/dl and increased triglycerides with mean 183.7 mg/ dl. (3) Majority of patients had microalbuminuria with mean 209.16 mg/dl/24 h. indian heart journal 67 (2015) s121–s133 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.elsevier.com/locate/ihj 0019-4832/