! "#$%&’# ()*+ ,--...#$%&’#/()*+)0 Full Length Research Paper Evaluation of the hepatoprotective, nephroprotective and anti-malarial activities of different parts of Bauhinia purpurae and Tipuana speciosa grown in Egypt Fahima F. Kassem 1 , Saleh I. Alqasoumi 2,3 , Shaimaa M. Sallam 1 , Adnan A. Bekhit 4 , Nagwa S. E. El-Shaer 1,5 , Abdallah I. Farraj 6 , Nabil A. Abdel-Salam 1 and Maged S. Abdel-Kader 1,3 * 1 Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt. 2 Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia. 3 Department of Pharmacognosy, College of Pharmacy, Salman Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Kingdom of Saudi Arabia. 4 Department of Pharmaceutical Chemistry, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt. 5 Department of Natural Products, Faculty of Pharmacy, King Abdul Aziz University, P. O. Box 80260, Jeddah 21589, Kingdom of Saudi Arabia. 6 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, P. O. Box 10219, Riyadh 11433, Kingdom of Saudi Arabia. Accepted 7 March, 2013 In an attempt to explore, the hepatoprotective, nephroprotective and anti-malarial effects of some plants growing in Egypt, different parts of Bauhinia purpurae and Tipuana speciosa family Fabaceae were selected for the current study. Liver and kidney injury were induced in Wistar albino rats using paracetamol. The biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflections of the liver condition. Measured kidney parameters were; serum creatinine, serum urea, sodium and potassium level. Liver and kidney samples of rats treated with extracts showed marked improvement in the biochemical parameters were subjected to histopathological study. All the results were compared with the reference drug silymarin. The anti-malarial activity was evaluated in vivo using Plasmodium berghei Infected mice and chloroquine phosphate as positive control. The tested extracts were used in three dose levels and activity was expressed as reduction in blood parasitemia and increase in the mouse survival time. The ethanol extract of B. purpurea flowers (BPFE) was effective in the three used assays. T. speciosa leaves extract (TSLE) showed good nephroprotective and anti-malarial activities. Key words: Hepatoprotection, nephroprotection, anti-malarial, Bauhinia purpurae, Tipuana speciosa, paracetamol, albino rats. INTRODUCTION In addition to their regulatory functions, both liver and kidney play an important role in detoxification and excre- tion of toxins; consequently they are exposed to high quantities of free radicals, which contribute to high oxida- tive stress (Abubaker et al., 2012; Pocock and Richards, 2006). Liver and kidney diseases represent two major 12))%+*$’*0 (-,) 3&’&,)&4,-&’#& 5% 6 78 66