International Journal of Research Publication and Reviews, Vol 4, no 3, pp 1752-1758, March 2023 International Journal of Research Publication and Reviews Journal homepage: www.ijrpr.com ISSN 2582-7421 Phytochemical and Pharmacological Activities of African Leaf (Vernonia Amygdalina): A Review 1 Oky Purnamasari, 2 Zikra Azizah, 3 Sestry Misfadhila 1,2,3 School of Pharmaceutical Science Padang (STIFARM Padang), West Sumatera, Indonesia, 25147 DOI: https://doi.org/10.55248/gengpi.2023.32773 A B S T R A C T African leaf (Vernonia amygdalina) belongs to the Asteraceae family. Vernonia amygdalina is one of the plants that can be widely consumed and used in traditional medicine in Asia and Africa. This plant has been widely studied for its health benefits, so obtaining information about its phytochemical content and pharmacological activity is necessary. This article summarizes research data from 2012-2022 that reports on the review of phytochemicals and pharmacological activities of Vernonia amygdalina. This review collected data from Google Scholar, Research Gate, and NCBI . The results showed that the Vernonia amygdalina plant contains phytochemical compounds flavonoids, alkaloids, saponins, triterpenoids, steroids, cardiac glycosides, tannins, anthraquinones, and oxytocin. Various bioactive compounds in this plant are used as antifertility, antioxidant, anti-diabetic, anti-cancer, antipyretic, anti-inflammatory, anti-microbial, analgesic, and hypercholesterolemia. African leaves (Vernonia amygdalina) show various pharmacological activities related to the content of bioactive compounds as traditional medicine. Keywords:Vernonia amygdalina, Phytochemical, PharmacologicalActivities INTRODUCTION African leaf, with the scientific name Vernonia amygdalina, is one of the plants extensively researched recently. This species is the most widely cultivated from the genus Vernonia. Vernonia amygdalina is a species from Africa and is quite commonly used in various traditional medicine in Indonesia and Africa. Vernonia amygdalina usually does not produce seeds, so stem cuttings do its cultivation. This plant generally lives in the wild and is found along drainage systems, commercial plantations, and forests in most areas of the tropics. This plant is known as a bitter leaf because of its very bitter taste the leaves. This plant is widely cultivated in African countries such as Nigeria, Cameroon, Ethiopia, and Zimbabwe. All parts of the plant have been found naturally pharmacologically helpful [1] [2] [3]. Figure 1. African Leaf (Vernonia amgydalina) Phytochemical compounds in Vernonia amygdalina are flavonoids, alkaloids, saponins, triterpenoids, steroids, cardiac glycosides, tannins, anthraquinones, and oxytocin. Several researchers found various classes of bioactive compounds contained in This plant cause Vernonia amygdalina to have multiple activities pharmacological agents can treat various diseases such as anti-diabetic, antioxidant, antipyretic, analgesic, toxicity, antifertility, anti-cancer, anti-inflammatory, and hypercholesterolemia. METHOD This review is based on searching data on scientific literature databases, namely Google scholar, research gate, and NCBI. This literature review was conducted to find evidence in the literature on the phytochemical and pharmacological activity of Vernonia amygdalina leaves. This journal review