Submit Manuscript | http://medcraveonline.com Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, Alkaline Phosphatase; Baso, Basophil; BS, Blood Sugar; CRP, C-reactive protein; COVID-19, severe acute respiratory syndrome coronavirus 2; CPK, Creatine Phosphokinase; Hb, Hemoglobin; Hct, hematocrit; ICU, intensive care unit; Lymph, Lymphocyte; LDH, lactate dehydrogenase; Mono, Monocyte; Neut, neutrophil; PLT, platelet; RBC Red, blood cell; WBC, white blood cell Introduction COVID-19 as a member of Coronaviridae family has a single- stranded, relatively enveloped, and positive-sense RNA, and leads to some acute diseases in animal species, particularly humans. 1 Coronaviruses are responsible for several diseases such as neurological, hepatic diseases, enteric, common cold and most importantly respiratory disorders in human species, though CoV-2 (SARS-CoV-2) or COVID-19 as the third zoonotic coronavirus in 21 st century is the most dangerous virus that causes severe acute respiratory syndrome with high spread and fatality rates in the globe. 2-4 The frst report of an infected case with COVID-19 was recorded in 2019 (December) in Wuhan, China. This disease then extensively and rapidly spread throughout worldwide through human-to-human transmission and quickly converted to be a disaster and pandemic disease in the world due to the lack of efective therapeutic strategies. It has been reported that approximately 50 million of people were infected by this virus in more than 200 countries and near to 1 million lost their life. However, it is predicated that the more mortality will be probably high in low-income countries due to the inadequate laboratories and health facilities. Thus, this epidemic is introduced as a serious public health concern by the World Health Organization (WHO). 5 There are mainly four structural proteins in this virus; (i) nucleocapsid protein, (ii) envelope protein, (iii) glycoprotein and (iv) matrix protein. It is demonstrated that the spike protein has an important role in invading of the virus to the host cells though the interaction with angiotensin-converting enzyme 2 (ACE2) as a common receptor in diferent human organs such as respiratory system, spleen, brain, kidney, lymph nodes, thymus and liver. 6 The symptoms of COVID-19, similar to the other viral infection are non-specifc and variable at initial stage, and commonly appear at the frst or second week after the infection. In most infected patients, mild type of fever, fatigue, dyspnea and dry cough are common symptoms, though the sever and advanced respiratory disorders are marked for this virus in sensitive cases, therefore, it requires rapid and selective detection, intensive treatment and management. Although the mortality rate of high-risk group such as immunocompromised, elderly, hypertensive and diabetic is more than healthy people, young and healthy people are present in the fatality statistic. Therefore, early diagnosis of the infected cases not only can help to control its spread, but also the pre- treatment can be begun. 7 Though molecular diagnosis is known as a gold-standard technique for COVID-19 detection, clinical characterization, and diferent laboratory parameters-hematological and biochemical factors- can be fundamental for the detection, monitoring of the treatment process and its related response to control this pandemic. Furthermore, obtaining these parameters in the infected cases can provide information to distinguish the high or low risk group for mortality and also enhance the awareness of clinical and epidemiological situational. Complete blood counts (CBC) is an example for hematological parameters that can be monitored as an infammatory marker for the detection. This study aimed to study clinical, biochemical and hematological data in the infected patients with COVID-19. 8,9 Biom Biostat Int J. 2021;10(2):68‒73. 68 ©2021 Vahidian et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Determining the clinical and experimental fndings of people with COVID-19 Volume 10 Issue 2 - 2021 Fatemeh Vahidian, 1,2,3 Souzan Najaf, 2 Vahid Khaze Shahgoli, 2,4 Elham Safarzadeh, 5 Moloud Akbarzadeh, 6,7 Seyed Isaac Hashemy 1 1 Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Iran 2 Immunology Research Center, Tabriz University of Medical Sciences, Iran 3 Department of Immunology, Faculty of medicine, Tabriz University of Medical Sciences, Iran 4 Department of Cancer and Infammation, Southern Denmark University, Denmark 5 Department of Microbiology& Immunology, School of Medicine, Ardabil University of Medical Sciences, Iran 6 Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Iran 7 Department of Cellular and Molecular Biology, Faculty of Biological Science, Azarbaijan Shahid Madani University, Iran Correspondence: Seyed Isaac Hashemy, Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Email Received: April 24, 2021 | Published: June 17, 2021 Abstract Introduction: Coronavirus disease 2019 (COVID-19) is responsible for severe acute respiratory syndrome. The present study planned to evaluate the accuracy of laboratory parameters and clinical fndings in predication of the infected cases through RT-PCR. Methods: All related laboratory tests of 180 cases (62.8% male and 37.2% female) with an average of 62 years old (45.3-69) were performed by several laboratory techniques. The obtained results as well as other clinical and biography fndings of the patients during the treatment and recovery were compared and analyzed to fnd out the possible relationship among the considered parameters. Results: The considered hematological and biochemistry factors were completely diferent in all cases regardless to their health and lifestyle condition, including being at ICU, being addict or not, whether having previous diseases or not and others. Conclusion: COVID-19 has brought a huge burden to the health system and infected patients, especially those who have a background of chronic diseases or addicted to some drugs. Keywords: COVID-19, laboratory experiments, clinical fnding, ICU Biometrics & Biostatistics International Journal Research Article Open Access