Submit Manuscript | http://medcraveonline.com Introduction One of the most important aspects of the critical care is to maintain normoglycemia in patients with established diabetes or stress-induced hyperglycemia. Hyperglycemia has been found to have a signifcant detrimental efect in those patients.1,2 Appropriate management of hyperglycemia had been found to have a signifcant impact on re- ducing mortality and admission duration as well as preventing of acute renal injury and providing faster weaning from mechanical ventilation.1,3,4 Moreover, hypoglycemia has its associated side efects5 and has been found to be an independent predictor of mortality in several studies.6,7 Furthermore, several organizations have determined their own target blood glucose levels for ICU patients8,9 and to achieve these goals, many hospitals use point-of-care (POC) glucose meters in order to monitor glycemic status. The using of POC glucose meters provides the advantage of portability, ease of use as well as readily available results which is signifcantly important in those patients who required tight glycemic control where waiting for central la-boratory results make the rapid adjustments and management of glucose level in therapy impractical. Most of the used meters have found to be accurate in stable outpatients however, among critically ill patients, results showed that there are various confounding factors that could interfere with POC glucometer as for example, hematocrit, oxygenation, acid- base disturbance, temperature and shock states.10,11 Considering presence of shock, several mechanisms had been discussed as possible explanations for its impact on accuracy of POC glucometers including that peripheral vasoconstriction in hypoperfusion states which could lead to increased the glucose extraction by tissues because of low capillary fow resulting in falsely underestimate of glu-cose measurement with capillary blood.12,13 Several publications concerning measuring blood glucose level in criti-cally ill patients showing acceptance variation with point of care results compared to laboratory results however they didn’t diferentiate between shocked relative to non-shocked patient [4,5]. Previous studies that had been con-ducted among critically ill patients included only small number of measurements taken for patients in shock that resulted in a heterogeneous cohort.1,14–19 Therefore, in this study, we aimed to compare the accuracy of point of care capillary and venous/arterial samples verse venous/arterial samples by laboratory testing in critically ill both shocked and non-shocked patients. Methodology This is a prospective case control study that was conducted among 268 critical ill patients who admitted to King Fahd Miliary Medical Complex Dhahran Saudi Arabia. Inclusion criteria included all adult, 18 years old and older, non-pregnant patients who admitted to the hospital with and without diabetes millitus after obtaining informed consent from primary decision makers. Exclusion criteria included hypovolemic shock because of severe active bleeding, patients with J Anesth Crit Care Open Access. 2022;14(3):91‒94. 91 ©2022 Alshaer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Comparing the accuracy of POC vers. Lab. (Capillary,Venous and arte-rial) blood glucose level in severely shocked verse non-shocked critically Ill patients Volume 14 Issue 3 - 2022 Abdulaziz Alshaer, Basma A Badgheish, Zahra Alsadah, Khalid Sewify, Sarah Alghazal, Sarah Alzahrani, Abeer Qadi, Reham Alqahtani, Amal Shilash Consultant Intensivist, Critical care Department, Saudi Arabia Correspondence: Abdulaziz Alshaer, Consultant Intensivist, Critical care Department, King Fahd Military Medical Complex Abqaiq road 31932 Dhahran, Saudi Arabia, Tel 00966552808060, Email Received: June 21, 2022 | Published: June 27, 2022 Abstract Background: Glucose monitoring among critically-ill patients has been a topic of attention for long time to prevent both hyperglycemia and hypoglycemia, which is important in an intensive care unit. Use of point of care blood glu-cose meters within some critically ill patient populations has resulted in varying degrees of confusion about of-label use and potential discrepancies in results. The aim of this study was to compare the accuracy of point of care capil-lary and venous/arterial samples verse venous/arterial samples by laboratory testing in critically ill both shocked and non-shocked patients. Methodology: This is prospective case control study that was conducted among 268 critical ill patients among whom, capillary, Venous and arterial Blood Sample during routine care which is requested by treating physician will be done by the same bedside nurse. The study was conducted in King Fahd Miliary Medical Complex Dhahran Saudi Arabia. Results: In this study, we were able to collect data for 268 patients. The results showed no signifcant diference between POCT and lap results of both of venous and central blood (P=0.389 and 0.208) where POCT showed slight-ly higher results with venous glucose concentration of 10.18 and 10.05 (POCT and lab tests respectively) and 9.18 and 9.54 in POCT and lab tests respectively. Moreover, the mean diference between POC and lab analysis of ve-nous, arterial and central glucose were 1.03, -1.8 and 0.7 mmol. Conclusion: We did not fnd a signifcant diference between results of POCT and regular laboratory analysis of glucose concentrations in critically ill patients except for arterial blood glucose. Using of POCT is slightly accurate with no diference between shocked and non-shocked patients compared to lab blood analysis. Journal of Anesthesia & Critical Care: Open Access Clinical Paper Open Access