Accepted Manuscript In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical-sized bone defects Mostafa Shahrezaee, Majid Salehi, Sara Keshtkari, Ahmad Oryan, Amir Kamali, Babak Shekarchi PII: S1549-9634(18)30481-7 DOI: doi:10.1016/j.nano.2018.06.007 Reference: NANO 1829 To appear in: Nanomedicine: Nanotechnology, Biology, and Medicine Received date: 14 March 2018 Revised date: 6 June 2018 Accepted date: 12 June 2018 Please cite this article as: Mostafa Shahrezaee, Majid Salehi, Sara Keshtkari, Ahmad Oryan, Amir Kamali, Babak Shekarchi , In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical- sized bone defects. Nano (2018), doi:10.1016/j.nano.2018.06.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.