Indian Journal of Clinical and Experimental Ophthalmology 2023;9(4):628–633 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Clinical and Experimental Ophthalmology Journal homepage: www.ijceo.org Original Research Article A cross-sectional study to evaluate ocular manifestations in chronic kidney disease patients in a tertiary care centre K Yamini 1 , Sangeetha T 1 *, H Mohan Kumar 2 , Kanthamani K 1 , Athish K K 1 , Raheel Mohamad 1 1 Dept. of Ophthalmology, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India 2 Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Bengaluru, Karnataka, India ARTICLE INFO Article history: Received 14-08-2023 Accepted 09-09-2023 Available online 29-12-2023 Keywords: Hypertension Diabetes Glomerular Creatinine Urea ABSTRACT Purpose: Chronic kidney disease (CKD) constitutes a major healthcare issue due to defective microcirculation secondary to systemic hypertension and diabetes mellitus. Hence, the aim is to find the prevalence of ocular pathology, risk factors and its association with the level of kidney function in patients with CKD undergoing haemodialysis. Materials and Methods: This prospective, cross-sectional study included 105 CKD patients referred to Ophthalmology Department in a tertiary care centre from November 2021 to April 2023. They were evaluated for demographic data, history of systemic comorbidities, visual acuity and ocular pathologies. This was correlated with the stages of CKD which is defined as the presence of glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 and/or proteinuria. Chi-square test or Fischer’s exact test was used as test of significance for qualitative data and Independent t test was used as test of significance to identify the mean difference between two quantitative variables. ANOVA was used as test of significance to identify the mean difference between more than two quantitative variables. Results: Out of 105 [74 (70.5%) male and 31(29.5%) females] CKD patients with mean age 58.43±13.05, ocular pathology was noted in 63 (60%) with hypertensive retinopathy in 47 (44.76%), diabetic retinopathy in 38 (36.19%), mixed retinopathy in 24 (22.85%), cataract in 24 (22.85%), glaucomatous changes in 5 (4.76%), ARMD in 4 (3.8%) and retinal vein occlusion in 3 (2.85%). The mean platelet volume also showed positive correlation with worsening stages of CKD (P-0.015), Hypertensive and diabetic retinopathy (P<0.001). Conclusion: Higher prevalence of ocular pathology 63 (60%) was observed in this study, re-emphasising that ocular screening is mandatory in all chronic kidney disease patients for early detection and initiation of prompt treatment to prevent ocular morbidity. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Chronic kidney disease (CKD) a major health problem worldwide, is associated with a wide range of complications leading to adverse health outcomes. The Kidney Disease Outcome Initiative Guidelines from 2002 describe it as kidney damage or a glomerular filtration rate of * Corresponding author. E-mail address: sangeetha31jayakumar@gmail.com (Sangeetha T). 60ml/min/1.73m2 for more than 3 months, regardless of the aetiology. 1 Albuminuria, defined as an albumin: creatinine ratio greater than 30mg/g in two of three spot urine samples, can demonstrate renal damage in numerous illnesses. Studies have found CKD to be associated with ocular disorders like age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract. Also, the retinal microvascular parameters are predictive of chronic kidney https://doi.org/10.18231/j.ijceo.2023.118 2395-1443/© 2023 Author(s), Published by Innovative Publication. 628