iMedPub Journals Our Site: http://www.imedpub.com/ © Copyright iMedPub 1 JOURNAL OF NEUROLOGY AND NEUROSCIENCE 2012 Vol. 3 No. 1:4 doi: 10.3823/328 Peripheral and central Vestibular function in patients with migraine Abstract This is a cross-sectional study evaluated vestibular function with migraine. Included were 58 patients [Migraine with aura (MA) = = 12; migraine without aura (MoA) = 46] (mean age = 31.60±9.17 and duration of illness = 8.33±4.47 years) and 40 healthy subjects. All underwent basic audiological evaluation, electronystag- mography (ENG) and auditory-brainstem response (ABR). We reported frequent vestibular manifestations in between the headache attacks (MA>MoA) includ- ing: dizziness (44.82%), rotatory vertigo (20.69%), positional vertigo (10.34%) and sense of imbalance (13.79%). Abnormalities ≥ one ENG tests were reported in 74.14% including: post head shaking (31.03%) positioning/positional testing (20.67%), OKN (24.14%), unilateral caloric weakness (17.24%), pursuit (13.79%) and saccadic (8.62%) eye tracking, gaze nystagmus (10.34%), spontaneous nys- tagmus (5.17%) and directional preponderance (6.9%). Phonophobia and tinnitus were reported in 10.34% and 13.79%. None had manifest hearing impairment but only 12 ears had pure tone audiometry abnormalities. ABR abnormalities were reported in 28% including: prolonged waves III latency and I-III, III-V and I-V IPLs. Frequency and duration of migraine were commonly associated with ENG and ABR abnormalities. Our results indicate that chronic migraine may result in permanent vestibular damage at any level of the peripheral or central vestibular pathways. This may lead to improved diagnosis, better prophylaxis and treatment of migraine and its related complications Key words: Migraine; vestibular function; vertigo; electronystagmography; caloric testing. Abbreviations: MA, migraine with aura; MoA, migraine without aura; ENG, elec- tronystagmography; PTA, pure-tone audiometry; UW, unilateral caloric weakness; DP, directional preponderance; ABR, auditory brainstem response; IPL, interpeak latency This article is available from: www.jneuro.com 1 Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt 2 Department of ENT, Audiology Unit, Assiut University Hospital, Assiut, Egypt Corresponding author:  hamed_sherifa@yahoo.com Sherifa Ahmad Hamed, MBBch., MSc., M.D Consultant Neurologist Professor, Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt P.O.Box 71516 Telephone: +2 088 2371820 Fax : +2 088 2333327 +2 088 2332278 Sherifa A. Hamed 1 , Amal Mohamad Elattar 2 Introduction Migraine is a common chronic presenting complaint with an estimated prevalence of 17.2% in women and 6% in men (1). Heritability in migraine was estimated to be between 40- 60% (2). Migraine is a complex disease that includes neu- rologic, gastrointestinal and autonomic symptoms, although headache is most common feature. Moderate to severe recur- rent attacks of migraine headache usually last for 4–72 hours. The common migraine or migraine without aura (MoA) is of- ten unilateral, pulsating (throbbing), may be associated with nausea and vomiting. In the classic migraine or migraine with aura (MA), headache is preceded by transient neurological symptoms as photophobia and phonophobia (3).