This is a Nivel certified Post Print, more info at nivel.nl Serious adverse events attributed to remifentanil patient-controlled analgesia during labour in The Netherlands S.L.M.Logtenberg, ab M.L.Vink, c M.B.Godfried, d I.C.M.Beenakkers, e F.G.Schellevis, fg B.W.Mol, h C.J.Verhoeven, ij a Amsterdam UMC, Academic Medical Centre, Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands b AVAG Amsterdam, Amsterdam, The Netherlands c Midwifery Practice Haarlemmermeer & Bollenstreek, Nieuw Vennep, The Netherlands d Department of Anesthesiology, OLVG, Amsterdam, The Netherlands e Department of Anesthesiology, Wilhelmina Children’s Hospital, Utrecht, The Netherlands f Amsterdam UMC, Vrije Universiteit Amsterdam, Department of General Practice & Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands g Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands h Department of Obstetrics and Gynaecology, Monash University Clayton, Clayton, Victoria, Australia i Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Midwifery Science, AVAG, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands j Maxima Medical Centre, Veldhoven, The Netherlands Abstract Background: During labour, remifentanil patient-controlled analgesia is used as an alternative to neuraxial analgesia. Remifentanil is associated with hypoventilation and respiratory depression but the frequency of serious maternal and neonatal adverse events is unknown. The aim of this study was to estimate the number of serious adverse events attributed to the use of remifentanil patient-controlled analgesia during labour in The Netherlands and to investigate the circumstances (e.g. monitoring, practice deviations) of these events and the subsequent management. Methods: In a nationwide survey among obstetricians, anaesthetists and clinical midwives the frequency of serious adverse events was assessed. A questionnaire was sent by email to Logtenberg, S.L.M., Vink, M.L., Godfried, M.B., Beenakkers, I.C.M., Schellevis, F.G., Mol, B.W., Verhoeven, C.J. Serious adverse events attributed to remifentanil patient-controlled analgesia during labour in The Netherlands. International Journal of obstetric Anesthesia: 2019, 3, p. 22-28 Postprint version : Journal website : https://www.obstetanesthesia.com/article/S0959-289X(18)30216- 4/fulltext Pubmed link : https://www.ncbi.nlm.nih.gov/pubmed/30509681 DOI : 10.1016/j.ijoa.2018.10.013 This is a Nivel certified Post Print, more info at nivel.nl