Magnetic Stimulation of Brain Cortex & Spinal Cord s311 1527-05) Osteoporotic postmenopausal spondylopathy with neurological complications A. Rusu, M. Sharov, V. Lisnic. Department of Neurology, Medical Sfafe Universi@ Kishinau, Republic of Moldova In addition to the simple spondylography 56 women with osteoporotic post- menopausal spondylopathy followed the quantitative computed tomography @CT) of the spondiles bodies and computed assisted myelography (CAM). The simple spondylography offers the possibility of the common estimation of the spinal column, presence of the fractures. It is possible to establish the initial osteoporotic changes, the prognosis of the risk of vertebral fractures by means of OCT. The density of the spondiles varied among 44 and 198 Haunsfield unites. Schmorf hernias were established in 32% cases. Stenosis of the spinal channel was revealed in 15 women (26% cases) by CAM. Indices of the motor evoked potentials were abnormal only at recording from the lower limb muscles. The central motor conduction time was increased in 73% cases. Electromyographical signs of denervation of the intercostales muscles were established in 43% cases. Electromyography and motor evoked potentials permit the preclinical diagnosis of the radicular and spinal involvement in the pathological process. 15-27-06 1 Superficial siderosis of central nervous system L. Sousa, E. Machado, A. Geraldo, M.A. Ferro, L. Cunha. Neurologic Department, Coimbra University Hospital, Coimbra, Portugal Superficial Siderosis (SS) of the CNS is a rare condition (about fifty reported cases since the first description in 1940 by No&l) characterized by the depo- sition of haemossiderin in leptomenings due to repeated chronic subarachnoid or intraventricular bleeding. The symptomatology of SS can range from asymp tomatic to a full blown clinical syndrome consisting of progressive sensorineural hearing loss, cerebellar dysfunction myelopathy and dementia. l/3 of the reported cases were idiopatic. A Case Report: a 45 years old woman had an episode of vertigo associated with a severe headache two years ago. She was otherwise normal with a past history of migraine without aura. In the past there was also a reported history of two episodes of head trauma. In the first clinical examination there was a slight ataxia with a right side desiquilibrtum and a horizontal bilateral nistagmus. A cranial and medular MR were performed and demonstrated the charac- teristic rim of hypointensity in T2 images on the surface of the cerebellum, brain steam, inferior part of cerebral hemispheres and spinal cord, consistent with haemossiderin deposits. Cerebreospinal fluid contained RBC(s) cells. Angicgraphic studies were negative. Treatment with trlentine dehydroclorid was shown a benefit effect. 5-27-07 Humoral immune response to mycobacterial heat shock protein 65 in the cerebrospinal fluid of neuro-Behcet patients 8. Tasci ’ , P. Serdaroglu ‘, H. Direskeneli ‘, G. Akman-Demir I, M. Eraksoy ’ , G. Saruhan-Direskeneli 3. ’ Department of Neurology Medical Faculty of Istanbul, capa, Istanbul, Turkeys 2 Division of Rheumatology Marmara Medical School, Turke)! 3Department of Physiolog) Medical Faculty of Istanbul & University of lstanbul Nectroneurophysio/ogy Research and Application Center, Turkey Although systemic immune reactivity to 65 kDa mycobacterial heat shock protein (m-HSP65) has been shown in Behpet’s disease (BD), local immune response was not investigated previously. We studied anti m-HSP65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 pa- tients with parenchymal neuro-Behpet’s disease (p-NBD), 7 NBD patients with intracranial hypertension (ih-NBD), 6 BD patients without CNS involvement, 30 with multiple sclerosis (MS) and 24 with non-inflammatory CNS disorders (NIC). 1) Significantly higher CSF IgG responses were detected in p-NBD pa- tients (ELISA ratio: 1.3 f 0.9) compared to NIC (0.7 f 0.4, p < 0.01). 2) CSF anti m-HSP65 IgM ratios did not show statistically significant differences on comparison of p-NBD to NIC, although p-NBD patients had higher values than the other groups. 3) In p-NBD patients IgG, IgM or IgA CSF anti m-HSP65 positivity rate was 48% (12/25), this was significantly higher when compared to MS (4/30; p < 0.03) and NIC (3/24; p < 0.01). 4) CSF anti m-HSP65 IgG ratios correlated with the duration of BD (r = 0.4, p < 0.04) but not with neurological involvement. These results implicate an increased local humoral immune response to m-HSP65 in CSFof p-NBD patients which might be related to the pathogenesis of neurological involvement. 5-27-08 Two year remission in melas treated with high dose CoQ and lipoinic acid H. Tireli, S. Mumoglu, K. Tutkavul, S. Ayta, G. Karlrkaya. Depatimenf Of Neurology, Haydarpa$a Numune Hospital, Istanbul, Turkey A twenty years old male with mitochondrial myopathy, encephalopathy, lactic acidemia and stroke like episodes is reported. In fourteens he had treated with GH and thyroid hormones because of the physical under-development. Neurosensory hearing disturbance appeared in sixteens; diarrhea, vomiting, generalized convulsions occurred one year later. After that, occipital cephalgia followed by status epilepticus was seen at two times. He had proximal weak- ness; lactic acidosis; and ragged-red fibers were found in muscle biopsy. The nt 3243 A-G mutation was detected. He had many attacks those were con- sist of recurrent ileus-like and stroke-like episodes, convulsions, hemianopia, hearing disturbance, sometimes accompanying unconsciousness. There were hyperintensities in occipitoparietotemporal regions in MR. He was treated with CoQ 300 mg/d, Camitine 2 g/d, vit.-C 2 s/d, vit-E 800 U/d, and antiepileptics. Lipoinic acid 600 mg/d was added in his treatment. In the beginning he had IO severe attacks in one year. After high dose CoQ and Lipoinic acid adminis- tration, his attacks became less severe and rare, neurologic status improved, hyperintense lesions in MR regressed. Our patient is in partial remission for two years with high dose CoQ and Lipoinic acid administration, 28 Magnetic Stimulation of Brain Cortex & Spinal Cord 15-28-01 1 Transcranial magnetic stimulation in patients with first-ever prolonged reversible ischemic neurological deficit P. Atanassova. Department of Neurology, Higher Medical Institute, Plovdiv, Bulgaria The aim of the study was to assess dynamic characteristics of the central motor conduction time (CMCT) and motor evoked potential (MEP) amplitudes in patients with first-ever prolonged reversible ischaemic neurological deficit (PRIND). Methods and Results: MEPs were recorded from musculus abductor pol- licis brevis bilaterally using surface eksctrodes on 7th and on 21st day after the accident in 38 patients and in 33 of them after 12 months. On the 7th day 6 patients had grade “0” according to modified Rankin scale, 16 - on 15th day, 13 - on 21st day, 3 - on 30th day. Five patients suffered recurrent strokes. There were decrease of the CMCT and facilitation of MEP amplitudes between 7th and 21st day, correlated to functional recovery. On 12th month CMCT was delayed and MEP amplitudes were decreased, compared with findings on 21st day. High percentage (13.2%) of recurrent strokes was discussed. Conclusion: Prognostic significance of CMCT and MEP amplitudes was not determined, but first-ever PRIND may be appreciated as a start of a process with new characteristics of conical motomeuron activity. 5-28-02 A new method for transcranial magnetic motor evoked potentials (TcMMEP) for the evaluation of central motor pathways (II. clinical appllcatlons) U.S. Benli, G. Nurlu, K. Varli, 0. Saribag. Departments of Neurolog): Baskent University Faculty of Medicine and Hacettepe University Faculty of Medicine, Ankara, Turkey The purpose of this study is to analyse the results of the clinical application of a new method of transcranial magnetic motor evoked potentials (TcMMEP) for the evaluation of central motor pathways. 30 patients (M: 18, F: 12; mean age: 41.6 f 13.2 years (r: 26-69)) were included in the study. The patients were monoparetic, paraparetic or quadrl- paretic. The responses were regarded as abnormal if the recordings are out of + 2 SD of normative data. In 25 of the patients TcMMEP showed abnormality. The level of central motor defect was thoracal in 4 patients, thoracolumbar in 8 and cervical in 13 patients. In two patients, the results of TcMMEP were false negative. The clinical correlation of the TcMMEP results was % 87.5 and subclinical abnormalities were detected in % 6.5 of the patients. In the same patient population SEP study results correlated with the clinical findings in % 71.3 of patients. The subclinical abnormality detected with SEP, was % 23.1. Magnetic resonance imaging performed in 27 patients, showed correlating lesions in 25.