85 Original article * Originálny článok Cardiology Lett. 2020;29(2):85–92 doi:10.4149/Cardiol_2020_2_5 Transmural dispersion of ventricular repolarization and its relation to incidence of malignant ventricular arrhythmias in patients afer myocardial infarction Transmurálna disperzia komorovej repolarizácie a jej vzťah k výskytu malígnych komorových arytmií u pacientov po infarkte myokardu Michálek P 1 , Hatahet SB 2 , Svetlošák M 3 , Margitfalvi P 3 , Waczulíková I 4 , Trnovec S 1 , Böhm A 2,5,6 , Beňačka O 1,3 , Hatala R 2,3 1 Lekárska fakulta Univerzity Komenského v Bratislave, Slovenská republika Michalek P, Hatahet SB, Svetlosak M, Margitfalvi P, Waczulikova I, Trnovec S, Böhm A, Benacka O, Hatala R. Transmural dispersion of ventricular repolarization and its relation to incidence of malignant ventricular arrhythmias in patients after myocardial infarction. Cardiology Lett. 2020;29(2):85–92 Abstract. Background: Potential of using the T-peak to T-end (TpTe) interval as an electrocardiographic parameter refecting the transmural dispersion of ventricular repolarization (TDR) to identify patients (pts.) with higher risk of malignant ventricular arrhythmias (MVA) for better selection of candidates for implantable cardioverter-defbrillator (ICD) in primary prevention (PP) of sudden cardiac death (SCD) remains controversial. Objective: The primary objective of this study was to investigate the relationship between the TpTe interval on a resting 12-lead electrocardiogram (ECG) and the incidence of MVA resulting in appropriate ICD inter- vention (AI). The secondary objective was to assess its relationship to overall mortality and analyze other clinical mortality predictors. Methods: A total of 243 consecutive pts. with severe left ventricular (LV) systolic dysfunction after myocar- dial infarction (MI) with a single chamber ICD in PP of SCD from one implantation center were included. We excluded all pts. with any other disease that could interfere with the indication of ICD implantation. Primarily investigated intervals were measured manually in accordance with accepted methodology. Data on ICD interventions were acquired from device interrogation during regular outpatient controls. Mortality data were collected from the database of insurance and regulatory authorities. Results: We did not fnd a signifcant relationship between the duration of the TpTe interval and the incidence of MVA (71.5 ms in pts. with MVA vs. 70 ms in pts. without MVA; p=0.408). Similar results were obtained for the corrected TpTe interval (TpTec) and the ratio of TpTe to QT interval (76.3 ms vs. 76.5 ms; p=0.539 and 0.178 vs. 0.181; p=0.547, respectively). There was also no signifcant diference between the duration of TpTe, TpTec and TpTe/QT ratio in pts. groups by overall mortality (71.5 ms in the deceased group vs. 70 ms in the survivors group; HR 1.01; 95% CI, 0.99 to 1.02; p=0.715, 76.3 ms vs. 76.5 ms; HR 1.01; 95% CI, 0.99 to 1.02; p=0.208 and 0.178 vs. 0.186; p=0.129, respectively). Signifcant factors afecting mortality included: higher age (HR 1.06; 95% CI, 1.04 to 1.09; p<0.001), lower ejection fraction of LV (HR 0.93; 95% CI, 0.89 to 0.97; p=0.001), higher serum creatinine (HR 1.01; 95% CI, 1.01 to 1.02; p<0.001), lower glomerular fltration rate (HR 0.98; 95% CI, 0.97 to 0.99; p<0.001), higher heart rate (HR 1.02; 95% CI, 1.00 to 1.03; p=0.024) and Z  1 Lekárskej fakulty Univerzity Komenského v Bratislave, 2 Lekárskej fakulty Slovenskej zdravotníckej univerzity v Bratislave, 3 Oddelenia arytmií a kar- diostimulácie Národného ústavu srdcových a cievnych chorôb, a. s., Bratislava, 4 Fakulty matematiky, fyziky a informatiky Univerzity Komenského v Bratislave, 5 Oddelenia akútnej kardiológie Národného ústavu srdcových a cievnych chorôb, a. s., Bratislava a  6 Academy Research Organization, Bratislava, Slovenská republika Do redakcie došlo dňa 13. februára 2020; prijaté dňa 26. februára 2020 Adresa pre korešpondenciu: MUDr. Peter Michálek, CINRE s.r.o., Tema- tínska 5/A, 851 05 Bratislava, Slovenská republika, e-mail: peter.michalek@ cinre.sk