Journal of Medical Laboratory Science, 2022; 32 (1): 1-22 http://jomls.org; info@jomls.org Christian and Eze http://doi.org/10.5281/zenodo.6386844 A Publication of the Association of Medical Laboratory Scientists of Nigeria, under a Creative Commons Attribution Non-Commercial 4.0 International Public License (CC BY-NC 4.0). 1 Evaluation of Some Haemostatic, Haematologic, ABO and Lewis Blood Group as Stroke Risk Factors in Ogoni Indigenes, Rivers State, Nigeria Serekara Gideon Christian, Evelyn Mgbeoma Eze Department of Medical Laboratory Science, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria ABSTRACT Objectives: The study evaluated haemostatic, haematologic, ABO and Lewis blood groups as stroke risk factors in Ogoni indigenes. Method: Full blood count was done using automation (SYSMEX). Activated partial thromboplastin time and prothrombin time was done using manual method. Factor VIII, von Willebrand factor, fibrinogen, D-dimer, tissue plasminogen activator was done using ELISA method. ABO, Lewis blood groups were analysed using standard tube methods. Results: Statistically significant increase was observed in white blood cell counts in blood group O (p = 0.0222), white blood cells higher in stroke group. For haemostatic parameters, statistically significant difference was observed in mean platelet volume (MPV) of blood group Le a (p < 0.0001), mean platelet volume lower in stroke group and activated partial thromboplastin time of blood group A versus stroke group (p = 0.0447). Conclusion: Based on odd ratios and likelihood ratios, the risk for stroke to occur due to blood group differences was in the order of: (B)>(Le- a)>(Le-b)>(A)>(O). Based on haemostatic values associated with selected blood groups which were not significant but relevant because of some marginally higher mean values of the stroke subjects against controls, they are not significantly associated as risk factors. However, based on odd ratios and likelihood ratios presence of blood group B, Le-a and Le-b antigens may be associated risk factors for stroke event. Keywords: Haemostatic; Haematologic; ABO Blood Group; Lewis Blood Group; Stroke; Ogoni *Correspondence:serekara.christian1@ust.edu.ng; +234-8038656722, ORCID:0000-0003-2169-8906; Evelyn Mgbeoma Eze, ORCID: 0000-0002-2727-6715. Author’s contributions: This work was carried out and approved in collaboration between all the authors who take responsibility for its intellectual contents, accuracy and integrity. SGC designed the study; SGC sourced for funding; SGC wrote the protocol; EME contributed in literature search; SGC and EME did Lab experiments; SGC did the statistical data analysis; SGC and EME contributed in the discussions; SGC drafted the manuscript; EME supervised the study; SGC Proof-read the galley proof for final publication Received: February/02, 2021; Accepted: January/25, 2022; Published: March/26, 2022. Citation: Christian SG and Eze EM. Evaluation of Some Haemostatic, Haematologic, ABO and Lewis Blood Group as Stroke Risk Factors in Ogoni Indigenes, Rivers State, Nigeria. J Med Lab Sci, 2022; 32 (1): 1-22