Journal Pre-proof Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events Hideki Imano, Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi PII: S0887-2333(20)30615-9 DOI: https://doi.org/10.1016/j.tiv.2020.105063 Reference: TIV 105063 To appear in: Toxicology in Vitro Received date: 26 August 2020 Revised date: 17 November 2020 Accepted date: 28 November 2020 Please cite this article as: H. Imano, R. Kato, Y. Ijiri, et al., Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events, Toxicology in Vitro (2020), https://doi.org/10.1016/j.tiv.2020.105063 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier.