International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 5 Issue 1, November-December 2020 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470 @ IJTSRD | Unique Paper ID – IJTSRD38190 | Volume – 5 | Issue – 1 | November-December 2020 Page 1375 Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride Mrs. Poonam Jaykar Patil 1 , Dr. Durgacharan A. Bhagwat 2 , Ms. Rutuja Rajendra Shah 3 , Dr. Jhon I. D’souza 4 1 Gahlot College of Pharmacy, Navi Mumbai, Maharashtra, India 2 Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India 3 Anandi College of Pharmacy, Kalambe Tarf Kale, Kolhapur, Maharashtra, India 4 Tatyasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India ABSTRACT Quick/slow drug delivery system involves the use of compressed core, consisting of sustained release tablet, which is coated by compression over the whole surface with fast dispersible formulation. Propranolol hydrochloride, a non-selective beta-adrenergic blocker has widely used in the treatment of hypertension and angina pectoris with frequent administration. Aim of present study was to develop press-coated tablet system to achieve quick/slow release of the drug are the main purposes of biphasic drug delivery system to avoid frequent administration with increasing patient compliance and therapeutic efficacy. In this study immediate layer which was prepared using croscarmellose sodium, crospovidone and sodium starch glycol ate which was compressed on core tablet prepared by using HPMC and Ethyl cellulose. Results showed that the immediate layer dissolved within four minutes and core tablet releases drug for 12 hrs in controlled manner with zero order release kinetics. KEYWORDS: Biphasic release; multiple unit dosage form; compressed tablets; Tablet characteristic, Tablet dissolution How to cite this paper: Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza "Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1, December 2020, pp.1375-1383, URL: www.ijtsrd.com/papers/ijtsrd38190.pdf Copyright © 2020 by author (s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0) 1. INTRODUCTION Oral drug delivery is largest and oldest segment of the total drug delivery market. 1 2 Since oral dosage form can be self administered by the patients they are more lucrative to manufacture. 3 The term modified-release drug product is used to describe products that alter the timing and/or the rate of release of the drug substance. conventional dosage forms such as solutions, ointments, or promptly dissolving dosage forms as presently recognized" . Several types of modified-release drug products are recognized. 4 Generally, conventional controlled dosage forms delay the release of therapeutic system levels and do not provide rapid onset of action. 5 To modify the release of drug from these systems, surface area exposed to fluid can be constrained by the addition of barrier layer to one or both side of the tablet. 6,7,8 The controlled release drug delivery system can improve therapeutic efficiency and safety of drug by precise and temporal spatial placement in the body, thereby reducing both the size and number of doses required. 9 When a single constant rate for drug release does not utterly satisfy the therapeutic objective, the quick/slow drug delivery system may be interesting alternative. 10 This biphasic release system can be achieved by the application of an immediate release layer to the conventional layered matrix tablet. 11 A quick/slow release system provides an initial burst of drug release followed by constant rate of release over a defined period of time. This type of system is used mostly when maximum relief needs to be achieved quickly, and it is followed by a sustained release phase to avoid repeated administration. 12 Suitable candidate drugs for this type of administration include non-steroidal anti inflammatory drugs, antihypertensive, antihistaminic and anti allergic agents. 13 Press-coating is absolute dry coating without solvent and heat use. 14 Propranolol hydrochloride is a nonselective beta- adrenergic blocking agent, 15 Propranolol hydrochloride undergoes extensive and highly variable hepatic first-pass metabolism following oral administration, with a reported systemic bioavailability between 15% and 23%. 16,17 18 . Propranolol hydrochloride was selected as a model drug here for the development of pH-independent extended release tablets. 19 . 20 Hydrophilic polymer matrix systems are widely used for designing oral controlled drug delivery IJTSRD38190