International Journal of Pharmaceutical Chemistry and Analysis 2023;10(2):100–109 Content available at: https://www.ipinnovative.com/open-access-journals International Journal of Pharmaceutical Chemistry and Analysis Journal homepage: https://www.ijpca.org/ Review Article Biophenols for cancer treatment: Current perspective and future potential Devesh U Kapoor 1 , Santosh Yele 2 , Bhupendra G Prajapati 3, * 1 Dayaram Patel Pharmacy College, Bardoli, Gujarat, India 2 SVKM’S NMIMS School of Pharmacy & Technology Management, Hyderabad, Telangana, India 3 Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India ARTICLE INFO Article history: Received 10-05-2023 Accepted 24-06-2023 Available online 01-07-2023 Keywords: Biophenol Cytotoxicity Hydroxychavicol Apoptosis Phytopharmaceuticals ABSTRACT Vegetable and natural product utilization are conversely connected with diminished malignant growth rate and mortality. Fruit antioxidants have been extensively studied for their ability to scavenge free radicals, preventing to develop the chronic degenerative diseases. As antiproliferative agents, mixtures of biophenols were more effective than individual biophenols. The tyrosol and hydroxytyrosol are major biophenol exist in olive samples. The other biophenol present in olive samples include lignans, verbascoside and flavonoids possessing anticancer properties. The Hydroxychavicol extracted from leaf of Piper betel also have chemotherapeutic and chemo preventive properties. Additionally, Curcumin also exhibited strong antit-tumor characteristics against a different type of cancers, including blood, breast, skin, colon, blood and prostrate. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction 1.1. Cancer in 21 st century Cancer is a common term employed for a group of disorders that are categorized by the uncontrollable growth of abnormal cells that can enter adjoining parts of body or may spread as well as to other parts. Cancer may also be termed as malignant tumours and neoplasms. It is not limited to any body part as it can affect almost any part of the body and do have various molecular and anatomic subtypes that each type requires specific strategy to manage it. 1 Globally, cancer is becoming a bigger problem for public health and is the second foremost cause of mortality after cardiac diseases. Lung, prostate, oral, stomach, and liver cancer are the most common types of cancer in men. On the other hand, breast, uterine, cervix, stomach, and uterine * Corresponding author. E-mail address: bhupendra.prajapati@ganpatuniversity.ac.in (B. G. Prajapati). cancer are the most common types of cancer in women. 2 WHO has stated that in 2005, from total of 58 million of deaths worldwide, 13% deaths were due to cancer. In 2012, about 15.2 million new cancer cases and 9.3 million mortality due to cancer occurred worldwide as per GLOBOCAN estimates. 3 In year 2015, 8.3 million deaths were due to cancer. Worldwide, currently more than 10 million cancer cases each year. In 2016 it was estimated that 11,323 children from birth to age of 15 years will be suffered with cancer and 1315 will be decease from cancer. 4 By the year 2025 cancer deaths are anticipated to surge considerably upto 17 million globally. 3,5 Various cancer-causing agents i.e. carcinogens are known. They may be physiological or biochemical such as tobacco and asbestos smoke, ultraviolet radiation, ionizing radiations, 6 several infections by bacteria (e.g., Helicobacter pylori cause gastric cancer), 7 virus (cervical cancer due to human papilloma virus and liver cancer due to hepatitis B virus), 8,9 parasites (e.g., schistosomiasis https://doi.org/10.18231/j.ijpca.2023.019 2394-2789/© 2023 Innovative Publication, All rights reserved. 100