Chemical Data Collections 30 (2020) 100566 Contents lists available at ScienceDirect Chemical Data Collections journal homepage: www.elsevier.com/locate/cdc Data Article A green, efficient protocol for the catalyst-free synthesis of tetrahydro-1H-pyrazolo-[3,4-b]-quinolin-5(4H)-ones supported by ultrasonicirradiation Lagudu Devi a , Kerru Nagaraju c , Suresh Maddila a,b,∗ , Sreekantha B. Jonnalagadda b a Department of Chemistry, GITAM Institute of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh, India b School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, South Africa c Department of Chemistry, GITAM School of Science, Bengaluru Campus, Karnataka – 561203, India GITAM University, India a r t i c l e i n f o Article history: Received 28 September 2020 Revised 9 October 2020 Accepted 11 October 2020 Available online 13 October 2020 Keywords: One-pot reaction Multicomponent synthesis Ultrasound irradiation Quinolines a b s t r a c t A green and efficient protocol for the one-pot, multicomponent, catalyst-free synthesis of tetrahydro-1H-pyrazolo-[3,4-b]-quinolin-5(4H)-ones (4a-j) from the reaction of 5-amino-3- methyl-1-phenylpyrazole, aromatic aldehydes, and dimedone in ethanol as green solvent under ultrasound irradiation is described. This protocol offers several benefits such as sim- ple handling, easy workup process, waste-free, milder reaction conditions, cleaner reaction, environment-friendly, short reaction times, absence of any tedious purification and excel- lent yields. © 2020 Elsevier B.V. All rights reserved. Specifications Table Subject area Green Chemistry Compounds Tetrahydro-1H-pyrazolo-[3,4-b]-quinolin-5(4H)-one derivatives Data category Synthesis, Structural characterization and Spectral data. Data acquisition format 1 H NMR, 13 C NMR, 15 N NMR, FT-IR and HR-MS spectral data. Data type Analyzed Procedure Synthesis of tetrahydro-1H-pyrazolo-[3,4-b]-quinolin-5(4H)-ones have been reported through catalyst-free, one-pot, multicomponent reaction in EtOH under ultrasound irradiation. 1. Rationale In view of the basic green chemistry conceptions, ultrasound (US) irradiation procedure is being showed to be a sig- nificant implement in the source of green chemistry [1]. Ultrasonic irradiation is a novel tendency in organic chemistry particularly in heterocyclic synthesis, suggesting a valuable and facile approach for a huge diversity of productions [1–3]. Therefore, a huge number of heterocyclic reactions may be carried out under US irradiation in less reaction times, milder reaction conditions and excellent yields [4]. Cavitation is the creation, evolution and breakdown of bubbles in an irradi- ated liquid. Then the consequence prompts with high local pressure and high temperatures inside the bubbles and develops ∗ Corresponding author. E-mail address: sureshmskt@gmail.com (S. Maddila). https://doi.org/10.1016/j.cdc.2020.100566 2405-8300/© 2020 Elsevier B.V. All rights reserved.