The Blockchain Technology: Benefits and Applications in Healthcare Information Systems Farzaneh Mohammadi 1 , Alireza Noruzi 2 1. Corresponding author, Master of Information Management, Department of Information Science and Knowledge Management, Faculty of Management, University of Tehran, Tehran, Iran: farzanehmohammadi@ut.ac.ir 2. Department of Information Science and Knowledge Management, Faculty of Management, University of Tehran, Tehran, Iran. E-mail: noruzi@ut.ac.ir Article Info ABSTRACT Article type: Review Article Article history: Received June 12, 2023 Received in revised form July 12, 2023 Accepted September 25, 2023 Published online December 25, 2023 Keywords: Blockchain, Security, Healthcare information systems, Electronic health records, Hyperledger fabric Objective: Healthcare information systems aim to provide high-quality healthcare services to ensure the security of patients’ health information. They can also assist in safeguarding an encyclopedia of clinical data to make more informed decisions in a private environment. However, the majority of today’s healthcare information systems are centralized and have great difficulty in providing indispensable information security and privacy, patient health records immutability, transparency, and flexibility to detect vulnerabilities and cyber invasions. Methods: The current study has explored the striking benefits and opportunities for blockchain technology in the healthcare information systems sector. It has identified the key applications that blockchain technology offers to provide indispensable information security and privacy, the immutability of patient health records, transparency, and flexibility to detect vulnerabilities and cyber invasions. Results: Blockchain technology as a regulatory technology can enhance healthcare information services by bringing high-quality healthcare services in a crystal clear view that is decentralized, immutable, tamper-resistant, flexible, traceable, and secure. It also enables clinical professionals to effectively detect vulnerabilities and cyber invasions related to patients’ health information. Conclusion: The practical deployment of blockchain technology in healthcare information systems takes years of research and experience to reach fruition. In order to enable the practical deployment of blockchain technology in healthcare information systems, a series of research will need to be conducted. Cite this article: Mohammadi, F., & Noruzi, A. (2023). The blockchain technology: Benefits and applications in healthcare information systems. Informology, 2(2), 95-116. © The Author(s). Publisher: Informology Center. Disclaimer/Publisher’s Note: The statements, opinions and data contained in the article are solely those of the individual author(s) and not of Informology and/or the editor(s). Informology and/or the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content.