This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record . Please cite this article as doi: 10.1111/adj.12658 This article is protected by copyright. All rights reserved Revised MS ADJ-06-18-0354 Anticariogenic efficacy of a saliva biomimetic in head-and-neck cancer patients undergoing radiotherapy Christina P.C. Sim*,†, Glenn D. Walker*, David J. Manton*, Yoke-Lim Soong‡, Joseph T.S. Wee‡, Geoffrey G. Adams*, Eric C. Reynolds* *Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Victoria, Australia †Dept of Restorative Dentistry, National Dental Centre, Singapore ‡Division of Radiation Oncology, National Cancer Centre, Singapore Address for correspondence: Professor E.C. Reynolds, Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Melbourne, Victoria, 3010, Australia. E-mail: e.reynolds@unimelb.edu.au Short title: CPP-ACP lowers radiation caries progression Acknowledgements This work was supported by the National Dental Centre Singapore Research Fund/National Medical Research Council Centre Grant and the Australian Government, Department of Industry, Innovation and Science. CPC Sim is a recipient of a Singapore National Medical Research Council Research Training Fellowship. GC Asia (Tokyo, Japan) provided the CPP-ACP and placebo products. ISRCTN Registration Information: ISRCTN14942820, DOI 10.1186/ISRCTN14942820 “The effect of a calcium delivery system on tooth decay in head and neck cancer patients treated by radiotherapy”. Author Manuscript