Research Article Preparation and Assessment of Some Characteristics of Nanoparticles Based on Sodium Alginate, Chitosan, and Camellia chrysantha Polyphenols Phu Hoang Luong, 1 Thuy Chinh Nguyen , 1,2 The Dan Pham, 3 Do Mai Trang Tran, 2 Thi Ngoc Lien Ly , 2 Quoc Trung Vu , 4 Thi Kim Ngan Tran, 1,5 and Hoang Thai 1,2 1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam 2 Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18, Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam 3 University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam 4 Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi 100000, Vietnam 5 NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam Correspondence should be addressed to Thuy Chinh Nguyen; thuychinhhn@gmail.com and Hoang Thai; hoangth@itt.vast.vn Received 28 January 2021; Revised 4 March 2021; Accepted 19 May 2021; Published 29 May 2021 Academic Editor: Zhonghua Peng Copyright © 2021 Phu Hoang Luong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper presents the characteristics, morphology, and properties of alginate/chitosan/polyphenol nanoparticles, in which polyphenols were extracted from Camellia chrysantha leaves collected in Tam Dao district, Vinh Phuc province (Vietnam). The alginate/chitosan/polyphenol nanoparticles were prepared by ionic gelation method at different polyphenol content. The characteristics and morphology of these nanoparticles were investigated using infrared spectroscopy (IR), ultraviolet- visible spectroscopy (UV-Vis), and scanning electron microscopy (SEM). Release kinetic of polyphenols from the alginate/chitosan/polyphenol nanoparticles was conducted in simulated human body fluids. The release kinetics of polyphenols from the above nanoparticles were also evaluated and discussed. The experimental results showed that the release process of polyphenols from the nanoparticles was dependent on three factors: time, pH of solution, and amount of polyphenols. 1. Introduction Polyphenols are family of naturally occurring compounds found in plants, with highly effective anti-inflammatory and antioxidation properties. It has been hypothesized that poly- phenols are able to protect cellular constituents against dete- rioration. They share a common structural motif, which consists of a benzene ring with one or more hydroxyl substit- uents attached directly to the aromatic nucleus. Depending on the number and location of attached hydroxyl groups, physical, chemical properties and biological activities of poly- phenols can be varied [1–3]. Camellia chrysantha, colloquially known as the golden flower tea, is a rare plant species found in Vietnam and China. It has many applications in biomedical field, with more than 400 valuable active ingredients, including polyphenol sapo- nins, trace elements such as selenium (Se), germanium (Ge), kalium (K), zinc (Zn), molybdenum (Mo), vanadium (V), manganese (Mn), and vitamins B 1 ,B 2 , and C. Additionally, golden flower tea also has the ability to prevent cardiovascular disease, hypertension, diabetes, and tumors [4]. Furthermore, polyphenols extracted from these species possess antibacterial and antioxidation characteristics that are attractive to research in the food and pharmaceutical fields. Hindawi International Journal of Polymer Science Volume 2021, Article ID 5581177, 11 pages https://doi.org/10.1155/2021/5581177