INTRODUCTION The contraceptive pill is one of the most common methods of contraception, as it began to be used in the sixties and contains the hormones estrogen and progesterone, or it is mono- hormonal and works to prevent ovulation at the same time. The mucus surrounding the cervix is thicker so it is difcult for sperm to pass through. 1 The knowledge of scientists about the hormonal control systems responsible for human reproduction enabled them to know the reverse systems, which are the substances that are used to prevent fertilization and implantation of the fetus or both to prevent pregnancy. In 1940, a method was developed in which hormones were used as contraceptives, and many researches continued until contraceptive drugs were developed, which are doses of the hormones estrogen and progesterone that are generally used as pills and are now known as oral steroid contraceptives. 2 The contraceptive pill is an efective means of family planning and reproductive health care for women who sufer from accompanying pregnancy problems such as hemorrhage, Acute anemia, and congenital hypertension. 3 Despite the appearance of some side efects of using these pills. It has gained great importance for their ease of use and its high efciency in contraception compared to other contraceptive methods. 4 Therefore, some studies have examined its benefts and harms. Contraceptive pills contain a mixture of estrogen-only hormones or both estrogenic and steroidal hormones, which are similar in concentration to natural female nitrogenous hormones. 5 The contraceptive pill with a passive feedback mechanism suppresses the gonadotrophin hormones secreted from the anterior lobe of the pituitary gland, which is a follicle- stimulating hormone and luteinizing hormone, by interfering with the function of the hypothalamic-ovarian axis. 6 Some studies have confrmed that the contraceptive pill increases the risk of breast and cervical cancer in women with a genetic history of this disease. 7 There are some side efects associated with the use of birth control pills headache, gingivitis, chest pain, nausea, vomiting, the appearance of black spots on the skin and its efect remains for a long time, Increased appetite and weight may increase, increased hirsutism and sudden bleeding. 8 It also causes depression by afecting the decrease in serotonin in the brain, as well as causing mood swings that tend to be sad. Benefts of contraceptive pills: Used to treat many health ABSTRACT This study was conducted to fnd out the use of oral contraceptive pills and their efect on some physiological blood parameters (platelet count, red blood cell count, white blood cell count, hemoglobin rate, physiological blood parameters, and cholesterol). The results between 10 women of reproductive age who were not taking oral contraceptives, and 10 women of reproductive age who were taking oral contraceptives showed no signifcant diferences among physiological blood parameters (p >0.05) but there were signifcant diferences among estrogen and progesterone hormones in women who did not take birth control pills. Keywords: Contraceptive pills, Blood parameters, Estrogen, Progesterone. International Journal of Pharmaceutical Quality Assurance (2023); DOI: 10.25258/ijpqa.14.4.04 How to cite this article: Al-Jassani MJ, Hasan SY, Adnan A, Allela OQB, Alsaraf KM, Kadhim AJ, Abdulwahid AS. The Efect of Contraceptive Pills on the Physiological Parameters of Blood and Hormones on Women in Al-Qurna, Iraq. International Journal of Pharmaceutical Quality Assurance. 2023;14(4):853-855. Source of support: Nil. Confict of interest: None The Efect of Contraceptive Pills on the Physiological Parameters of Blood and Hormones on Women in Al-Qurna, Iraq Mohammad J Al-Jassani 1* , Saif Y Hasan 2 , Ahmed Adnan 3 , Omer QB Allela 4 , Khulood M Alsaraf 5 , Abed J Kadhim 6 , Alzahraa S Abdulwahid 7 1 Department of Forensic Science, College of Science, Al-Karkh University of Science, Iraq. 2 College of Health and Medical Technology, National University of Science and Technology, Thi-Qar, Iraq. 3 Al-Manara College For Medical Sciences, Maysan, Iraq. 4 College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq. 5 Department of Medical Lab. Techniques, Al-Esraa University College, Baghdad, Iraq. 6 Department of Medical Lab. Techniques, Al-Nisour University College, Iraq. 7 Department of Medical Lab. Techniques, Al-Hadi University College Baghdad, Iraq. Received: 18 nd October, 2023; Revised: 26 th October, 2023; Accepted: 14 th November, 2023; Available Online: 25 th December, 2023 RESEARCH ARTICLE *Author for Correspondence: pcr2000@yahoo.com